methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate

Base Information

Chemical Name:methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate
CAS No.:176308-95-5
Molecular Formula:C₁₀H₁₁ClO₄S
Molecular Weight:262.714
Hs Code.:

Synonyms:methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate

Suppliers and Price of methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-2-methyl-5-(methylsulfonyl)-benzoicAcidMethylEster
500mg
$ 1485.00

Total 2 raw suppliers

Chemical Property of methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

4-Chloro-2-methyl-5-(methylsulfonyl)-benzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-Chloro-2-methyl-5-(methylsulfonyl)-benzoic Acid Methyl Ester is an intermediate in the synthesis of Rimeporide Hydrochloride (R517200) which is used for the treatment of diseases associated with insulin resistance and beta-cell dysfunction.

Technology Process of methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate

There total 4 articles about methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7499-07-2
4-chloro-2-methylbenzoic acid

: 7757-83-7
sodium sulfite

: 74-88-4
methyl iodide

: 176308-95-5
methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate

Guidance literature:: With chlorosulfonic acid; In methanol; water;

Reference yield:

: 213121-77-8
2-chloro-4-methyl-5-carboxybenzenesulfinic acid

: 74-88-4
methyl iodide

: 176308-95-5
methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate

Guidance literature:: With sodium hydroxide; potassium carbonate; In N,N-dimethyl-formamide; for 5h; Yield given; Heating;
DOI:10.1021/jm960768n

Reference yield:

: 7499-07-2
4-chloro-2-methylbenzoic acid

: 176308-95-5
methyl 2-methyl-4-chloro-5-methylsulphonylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: ClSO₃H / 6 h / 135 - 140 °C

2: aq. Na₂SO₃, aq. NaOH / 15 - 20 °C

3: aq. NaOH / methanol / 30 h / Heating

With chlorosulfonic acid; sodium hydroxide; sodium sulfite; In methanol;
DOI:10.1021/jm960768n