(+)-(4R)-4-{(1S)-2-(benzyloxy)-2-methyl-1-[(methylsulfanyl)methoxy]propyl}-2,2-dimethyl-1,3-dioxolane

Base Information

Chemical Name:(+)-(4R)-4-{(1S)-2-(benzyloxy)-2-methyl-1-[(methylsulfanyl)methoxy]propyl}-2,2-dimethyl-1,3-dioxolane
CAS No.:502614-13-3
Molecular Formula:C₁₈H₂₈O₄S
Molecular Weight:340.484
Hs Code.:

Synonyms:(+)-(4R)-4-{(1S)-2-(benzyloxy)-2-methyl-1-[(methylsulfanyl)methoxy]propyl}-2,2-dimethyl-1,3-dioxolane

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Chemical Property of (+)-(4R)-4-{(1S)-2-(benzyloxy)-2-methyl-1-[(methylsulfanyl)methoxy]propyl}-2,2-dimethyl-1,3-dioxolane

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Technology Process of (+)-(4R)-4-{(1S)-2-(benzyloxy)-2-methyl-1-[(methylsulfanyl)methoxy]propyl}-2,2-dimethyl-1,3-dioxolane

There total 7 articles about (+)-(4R)-4-{(1S)-2-(benzyloxy)-2-methyl-1-[(methylsulfanyl)methoxy]propyl}-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-39-0
benzyl bromide

: 502614-16-6
(+)-(1S)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-methyl-1-[(methylsulfanyl)methoxy]propan-2-ol

: 502614-13-3
(+)-(4R)-4-{(1S)-2-(benzyloxy)-2-methyl-1-[(methylsulfanyl)methoxy]propyl}-2,2-dimethyl-1,3-dioxolane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1002/hlca.200390328

Reference yield:

: 502614-15-5
(-)-(1S)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-methylpropane-1,2-diol

: 502614-13-3
(+)-(4R)-4-{(1S)-2-(benzyloxy)-2-methyl-1-[(methylsulfanyl)methoxy]propyl}-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / AcOH; Ac₂O / 38 h / 20 °C

2: 96 percent / NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

With acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; In tetrahydrofuran;
DOI:10.1002/hlca.200390328

Reference yield:

: 83657-30-1
(+)-(1S)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-hydroxypropan-2-one

: 502614-13-3
(+)-(4R)-4-{(1S)-2-(benzyloxy)-2-methyl-1-[(methylsulfanyl)methoxy]propyl}-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / tetrahydrofuran; diethyl ether / 1 h / 20 °C

2: 58 percent / AcOH; Ac₂O / 38 h / 20 °C

3: 96 percent / NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

With acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; In tetrahydrofuran; diethyl ether;
DOI:10.1002/hlca.200390328