tert-butyl 3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzylcarbamate

Base Information

Chemical Name:tert-butyl 3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzylcarbamate
CAS No.:1346447-88-8
Molecular Formula:C₂₄H₂₇ClN₆O₃
Molecular Weight:482.97
Hs Code.:

Synonyms:tert-butyl 3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzylcarbamate

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Chemical Property of tert-butyl 3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzylcarbamate

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Technology Process of tert-butyl 3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzylcarbamate

There total 6 articles about tert-butyl 3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 147291-66-5
3-tert-butoxycarbonylaminomethylaniline

: 1346447-88-8
tert-butyl 3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzylcarbamate

Guidance literature:: With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In iso-butanol; at 80 ℃; for 6h;

Reference yield:

: 7409-18-9
3-nitrobenzylamine

: 1346447-88-8
tert-butyl 3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; tetrahydrofuran / 1 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h / 20 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / iso-butanol / 6 h / 80 °C

With hydrogen; potassium carbonate; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In tetrahydrofuran; ethanol; water; iso-butanol;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1346447-88-8
tert-butyl 3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; tetrahydrofuran / 1 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h / 20 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / iso-butanol / 6 h / 80 °C

With hydrogen; potassium carbonate; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In tetrahydrofuran; ethanol; water; iso-butanol;