C₂₉H₃₆O₂Si

Base Information

• Chemical Name: C₂₉H₃₆O₂Si
• CAS No.: 1370368-72-1
• Molecular Formula: C₂₉H₃₆O₂Si
• Molecular Weight: 444.689
• Mol file: 1370368-72-1.mol

Synonyms:C₂₉H₃₆O₂Si

Chemical Property of C₂₉H₃₆O₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₆O₂Si

There total 4 articles about C₂₉H₃₆O₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-1-(benzyloxy)-3-hydroxyhex-5-ene (91285-62-0,111322-01-1,119239-98-4) + tert-butylchlorodiphenylsilane (58479-61-1) → C29H36O2Si (1370368-72-1)

Guidance literature:

With 1H-imidazole; dmap; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2012.02.025

Reference yield:

benzyl bromide (100-39-0) → C29H36O2Si (1370368-72-1)

Guidance literature:

Multi-step reaction with 4 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

2: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

3: bis(((S)-binaphthoxy)(isopropoxy)titanium) oxide / dichloromethane / 72 h / -20 °C / Molecular sieve

4: 1H-imidazole; dmap / dichloromethane / 4 h / 0 - 20 °C

With 1H-imidazole; dmap; bis(((S)-binaphthoxy)(isopropoxy)titanium) oxide; tetra-(n-butyl)ammonium iodide; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 3: Maruoka asymmetric allylation;

DOI:10.1016/j.bmcl.2012.02.025

Reference yield:

3-Benzyloxypropanal (19790-60-4) → C29H36O2Si (1370368-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(((S)-binaphthoxy)(isopropoxy)titanium) oxide / dichloromethane / 72 h / -20 °C / Molecular sieve

2: 1H-imidazole; dmap / dichloromethane / 4 h / 0 - 20 °C

With 1H-imidazole; dmap; bis(((S)-binaphthoxy)(isopropoxy)titanium) oxide; In dichloromethane; 1: Maruoka asymmetric allylation;

DOI:10.1016/j.bmcl.2012.02.025

upstream raw materials:

3-benzyloxypropan-1-ol

3-Benzyloxypropanal

(S)-1-(benzyloxy)-3-hydroxyhex-5-ene

tert-butylchlorodiphenylsilane

Downstream raw materials:

(S)-3-(tert-butyldiphenylsiloxy)hex-5-en-1-ol

C₂₂H₂₈O₂Si

(3R,5S)-5-(tert-butyldiphenylsiloxy)-1-phenyloct-7-en-1-yn-3-ol

(3S,5S)-5-(tert-butyldiphenylsiloxy)-1-phenyloct-7-en-1-yn-3-ol