tert-butyl{[(1R,2R,3R,4E)-1-{(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-3-methoxy-2-methyl-5-phenyl-4-pentenyl]oxy}dimethylsilane

Base Information

Chemical Name:tert-butyl{[(1R,2R,3R,4E)-1-{(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-3-methoxy-2-methyl-5-phenyl-4-pentenyl]oxy}dimethylsilane
CAS No.:1374458-68-0
Molecular Formula:C₃₈H₅₆O₃Si₂
Molecular Weight:617.032
Hs Code.:

Synonyms:tert-butyl{[(1R,2R,3R,4E)-1-{(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-3-methoxy-2-methyl-5-phenyl-4-pentenyl]oxy}dimethylsilane

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Chemical Property of tert-butyl{[(1R,2R,3R,4E)-1-{(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-3-methoxy-2-methyl-5-phenyl-4-pentenyl]oxy}dimethylsilane

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Technology Process of tert-butyl{[(1R,2R,3R,4E)-1-{(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-3-methoxy-2-methyl-5-phenyl-4-pentenyl]oxy}dimethylsilane

There total 9 articles about tert-butyl{[(1R,2R,3R,4E)-1-{(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-3-methoxy-2-methyl-5-phenyl-4-pentenyl]oxy}dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1374458-67-9
(2R,3R,4S,5R,6E)-1-[(tert-butyldiphenylsilyl)oxy]-5-methoxy-2,4-dimethyl-7-phenyl-6-hepten-3-ol

: 69739-34-0
t-butyldimethylsiyl triflate

: 1374458-68-0
tert-butyl{[(1R,2R,3R,4E)-1-{(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-3-methoxy-2-methyl-5-phenyl-4-pentenyl]oxy}dimethylsilane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -50 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/ejoc.201101635

Reference yield:

: 1374458-62-4
(2R,3R,E)-1-((R)-4-benzyl-2-thioxothiazolidin-3-yl)-3-hydroxy-2-methyl-5-phenylpent-4-en-1-one

: 1374458-68-0
tert-butyl{[(1R,2R,3R,4E)-1-{(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-3-methoxy-2-methyl-5-phenyl-4-pentenyl]oxy}dimethylsilane

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -78 °C / Inert atmosphere

2.1: benzene / 12 h / 80 °C / Inert atmosphere

3.1: silver(l) oxide / 36 h / 50 °C / Darkness; Inert atmosphere

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere

5.1: L-(+)-diisopropyl tartrate; titanium(IV)isopropoxide / dichloromethane / 0.5 h / -23 °C / Molecular sieve; Inert atmosphere

5.2: 18 h / -23 °C / Inert atmosphere

6.1: diethyl ether / 1.5 h / -45 °C / Inert atmosphere

7.1: 1H-imidazole; dmap / dichloromethane / 1 h / -5 °C / Inert atmosphere

8.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / -50 °C / Inert atmosphere

With 1H-imidazole; 2,6-dimethylpyridine; dmap; L-(+)-diisopropyl tartrate; titanium(IV)isopropoxide; diisobutylaluminium hydride; silver(l) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; benzene; 2.1: Wittig reaction / 5.1: Katsuki-Sharpless epoxidation / 5.2: Katsuki-Sharpless epoxidation;
DOI:10.1002/ejoc.201101635

Reference yield:

: 1374458-63-5
ethyl (2E,4S,5R,6E)-5-hydroxy-4-methyl-7-phenyl-2,6-heptadienoate

: 1374458-68-0
tert-butyl{[(1R,2R,3R,4E)-1-{(1R)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-3-methoxy-2-methyl-5-phenyl-4-pentenyl]oxy}dimethylsilane

Guidance literature:: Multi-step reaction with 6 steps

1.1: silver(l) oxide / 36 h / 50 °C / Darkness; Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere

3.1: L-(+)-diisopropyl tartrate; titanium(IV)isopropoxide / dichloromethane / 0.5 h / -23 °C / Molecular sieve; Inert atmosphere

3.2: 18 h / -23 °C / Inert atmosphere

4.1: diethyl ether / 1.5 h / -45 °C / Inert atmosphere

5.1: 1H-imidazole; dmap / dichloromethane / 1 h / -5 °C / Inert atmosphere

6.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / -50 °C / Inert atmosphere

With 1H-imidazole; 2,6-dimethylpyridine; dmap; L-(+)-diisopropyl tartrate; titanium(IV)isopropoxide; diisobutylaluminium hydride; silver(l) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 3.1: Katsuki-Sharpless epoxidation / 3.2: Katsuki-Sharpless epoxidation;
DOI:10.1002/ejoc.201101635