tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate

Base Information

Chemical Name:tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate
CAS No.:906793-21-3
Molecular Formula:C₂₆H₄₁N₃O₄Si
Molecular Weight:487.715
Hs Code.:

Synonyms:tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate

Suppliers and Price of tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate

There total 4 articles about tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 906793-20-2
tert-butyl (1R,2S,3R)-3-hydroxy-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 906793-21-3
tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/ol061223i

Reference yield:

: 906792-93-6
((3R,4S,5R)-2-benzyl-5-methyl-3-phenylisoxazolidin-4-yl)(1-methyl-1H-imidazol-2-yl)methanone

: 906793-21-3
tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / hydrogen / Pd(OH)2/C / methanol / 20 °C / 760 Torr

2: 99 percent / imidazole / dimethylformamide / 0 - 20 °C

With 1H-imidazole; hydrogen; palladium dihydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol061223i

Reference yield:

: 3376-26-9
N-Benzylidenebenzylamine N-oxide

: 906793-21-3
tert-butyl (1R,2S,3R)-3-(tert-butyldimethylsilyloxy)-2-(1-methyl-1H-imidazole-2-carbonyl)-1-phenylbutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / molecular sieves 4 Angstroem / chiral bis(oxazolinyl)pyridine-cerium(IV) triflate complex / ethyl acetate / 17 h / 0 °C

2: 80 percent / hydrogen / Pd(OH)2/C / methanol / 20 °C / 760 Torr

3: 99 percent / imidazole / dimethylformamide / 0 - 20 °C

With 1H-imidazole; 4 A molecular sieve; hydrogen; palladium dihydroxide; chiral bis(oxazolinyl)pyridine-cerium(IV) triflate; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol061223i