2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

Base Information

Chemical Name:2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide
CAS No.:1288963-61-0
Molecular Formula:C₂₀H₁₇N₃O₂S
Molecular Weight:363.44
Hs Code.:

Synonyms:2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

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Chemical Property of 2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

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Technology Process of 2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

There total 7 articles about 2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1288963-89-2
2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

: 1288963-61-0
2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

: 1288963-60-9
2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Guidance literature:: With hydroxylamine; In methanol; water; at 130 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1288963-61-0
2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

: 1288963-60-9
2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide / dichloromethane / 0.03 h

4: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

5: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

6: boron fluoride-dimethyl sulfide complex / dichloromethane / 16 h / 0 - 2 °C

7: hydroxylamine / water; methanol / 0.33 h / 130 °C / Microwave irradiation

With methanol; N-Bromosuccinimide; boron fluoride-dimethyl sulfide complex; hydroxylamine; sodium hydride; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 99655-68-2
3-bromo-1-phenylsulfonyl indole

: 1288963-61-0
2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

: 1288963-60-9
2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide / dichloromethane / 0.03 h

4: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

5: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

6: boron fluoride-dimethyl sulfide complex / dichloromethane / 16 h / 0 - 2 °C

7: hydroxylamine / water; methanol / 0.33 h / 130 °C / Microwave irradiation

With methanol; N-Bromosuccinimide; boron fluoride-dimethyl sulfide complex; hydroxylamine; sodium hydride; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;