2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Base Information

Chemical Name:2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide
CAS No.:1288963-60-9
Molecular Formula:C₂₀H₁₈N₄O₂S
Molecular Weight:378.455
Hs Code.:

Synonyms:2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Suppliers and Price of 2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

There total 7 articles about 2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1288963-89-2
2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

: 1288963-61-0
2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

: 1288963-60-9
2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Guidance literature:: With hydroxylamine; In methanol; water; at 130 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1288963-61-0
2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

: 1288963-60-9
2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide / dichloromethane / 0.03 h

4: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

5: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

6: boron fluoride-dimethyl sulfide complex / dichloromethane / 16 h / 0 - 2 °C

7: hydroxylamine / water; methanol / 0.33 h / 130 °C / Microwave irradiation

With methanol; N-Bromosuccinimide; boron fluoride-dimethyl sulfide complex; hydroxylamine; sodium hydride; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 99655-68-2
3-bromo-1-phenylsulfonyl indole

: 1288963-61-0
2-(3,5-dimethylisothiazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carboxamide

: 1288963-60-9
2-(3,5-dimethylisothiazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1H-indole-1-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide / dichloromethane / 0.03 h

4: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

5: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

6: boron fluoride-dimethyl sulfide complex / dichloromethane / 16 h / 0 - 2 °C

7: hydroxylamine / water; methanol / 0.33 h / 130 °C / Microwave irradiation

With methanol; N-Bromosuccinimide; boron fluoride-dimethyl sulfide complex; hydroxylamine; sodium hydride; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;