4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide

Base Information

Chemical Name:4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide
CAS No.:1187448-62-9
Molecular Formula:C₁₈H₁₈FN₃O₃S
Molecular Weight:375.424
Hs Code.:

Synonyms:4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide

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Chemical Property of 4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide

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Technology Process of 4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide

There total 9 articles about 4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: N-(2-hydroxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide

: 1187449-21-3
4-bromo-2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridine

: 1187448-62-9
4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide

Guidance literature:: With potassium phosphate; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 869557-43-7
3-bromo-5-fluoropyridin-2-amine

: 1187448-62-9
4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 5.5 h / 75 °C / Inert atmosphere

2: potassium tert-butylate / N,N-dimethyl-formamide / 24 h / 30 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / -20 - 20 °C / Inert atmosphere

4: tetramethylammonium bromide; Methanesulfonic anhydride / N,N-dimethyl-formamide / -20 - 20 °C / Inert atmosphere

5: potassium phosphate / 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

With potassium phosphate; copper(l) iodide; potassium tert-butylate; tetramethylammonium bromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; Methanesulfonic anhydride; bis-triphenylphosphine-palladium(II) chloride; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 6746-94-7
Cyclopropylacetylene

: 1187448-62-9
4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 5.5 h / 75 °C / Inert atmosphere

2: potassium tert-butylate / N,N-dimethyl-formamide / 24 h / 30 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / -20 - 20 °C / Inert atmosphere

4: tetramethylammonium bromide; Methanesulfonic anhydride / N,N-dimethyl-formamide / -20 - 20 °C / Inert atmosphere

5: potassium phosphate / 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

With potassium phosphate; copper(l) iodide; potassium tert-butylate; tetramethylammonium bromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; Methanesulfonic anhydride; bis-triphenylphosphine-palladium(II) chloride; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;