(4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone

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Chemical Name:(4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone
CAS No.:1227159-58-1
Molecular Formula:C₂₈H₃₄N₆O₂Si
Molecular Weight:514.702
Hs Code.:

Synonyms:(4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone

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Chemical Property of (4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone

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Technology Process of (4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone

There total 6 articles about (4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1225380-15-3
C₁₀H₁₆N₂OSi

: 1225380-88-0
5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboxylic acid

: 1227159-58-1
(4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone

Guidance literature:: 5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

C₁₀H₁₆N₂OSi; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

In dimethyl sulfoxide; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 126062-63-3
1,1-dimethylethyl 3-bromomethylbenzoate

: 1227159-58-1
(4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 16 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / Inert atmosphere

3.2: 16 h / 20 °C

4.1: sodium hydroxide / ethanol / 2 h / 70 °C

4.2: pH Ca_.4

5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

5.2: 1 h / 0 - 20 °C

5.3: 0.5 h / 120 °C / Microwave irradiation

With oxalyl dichloride; potassium tert-butylate; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1227159-58-1
(4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 16 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / Inert atmosphere

3.2: 16 h / 20 °C

4.1: sodium hydroxide / ethanol / 2 h / 70 °C

4.2: pH Ca_.4

5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

5.2: 1 h / 0 - 20 °C

5.3: 0.5 h / 120 °C / Microwave irradiation

With oxalyl dichloride; potassium tert-butylate; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;