(5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine

Base Information

Chemical Name:(5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine
CAS No.:1351564-83-4
Molecular Formula:C₂₀H₁₁F₆N₃O₂S
Molecular Weight:471.383
Hs Code.:

Synonyms:(5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine

Suppliers and Price of (5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine

There total 2 articles about (5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140690-56-8
2,4-bis(trifluoromethyl)benzyl bromide

: 1351564-83-4
(5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: ammonium acetate; acetic acid / 12 h

With ammonium acetate; caesium carbonate; acetic acid; In N,N-dimethyl-formamide; 2: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 253801-04-6
1H-indazole-5-carbaldehyde

: 1351564-83-4
(5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: ammonium acetate; acetic acid / 12 h

With ammonium acetate; caesium carbonate; acetic acid; In N,N-dimethyl-formamide; 2: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield: 42.0%

: 123-75-1
pyrrolidine

: 1351564-83-4
(5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine

: 107-04-0
1-Bromo-2-chloroethane

: 1351566-43-2
(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione

Guidance literature:: (5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine; 1-Bromo-2-chloroethane; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

pyrrolidine; In N,N-dimethyl-formamide; at 80 ℃; for 12h;
DOI:10.1016/j.ejmech.2017.07.015