(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione

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Chemical Name:(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione
CAS No.:1351566-43-2
Molecular Formula:C₂₆H₂₂F₆N₄O₂S
Molecular Weight:568.543
Hs Code.:

Synonyms:(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione

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Chemical Property of (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione

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Technology Process of (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione

There total 5 articles about (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 123-75-1
pyrrolidine

: 1351564-83-4
(5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine

: 107-04-0
1-Bromo-2-chloroethane

: 1351566-43-2
(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione

Guidance literature:: (5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl} methylidene)-2,4-dioxo-1,3-thiazolidine; 1-Bromo-2-chloroethane; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

pyrrolidine; In N,N-dimethyl-formamide; at 80 ℃; for 12h;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 140690-56-8
2,4-bis(trifluoromethyl)benzyl bromide

: 1351566-43-2
(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2.1: ammonium acetate; acetic acid / 12 h

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3.2: 12 h / 80 °C

With ammonium acetate; potassium carbonate; caesium carbonate; acetic acid; In N,N-dimethyl-formamide; 2.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 253801-04-6
1H-indazole-5-carbaldehyde

: 1351566-43-2
(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2.1: ammonium acetate; acetic acid / 12 h

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3.2: 12 h / 80 °C

With ammonium acetate; potassium carbonate; caesium carbonate; acetic acid; In N,N-dimethyl-formamide; 2.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2017.07.015