2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

Base Information

Chemical Name:2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile
CAS No.:1400867-30-2
Molecular Formula:C₁₆H₁₅FN₂OS
Molecular Weight:302.372
Hs Code.:

Synonyms:2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

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Chemical Property of 2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

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Technology Process of 2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

There total 7 articles about 2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1056549-88-2
2-methoxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 1232674-98-4
2-bromo-2-(2-fluorophenyl)acetonitrile

: 1400867-30-2
2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

Guidance literature:: With potassium carbonate; In ethanol; at 0 ℃;
DOI:10.1016/j.tetlet.2012.07.071

Reference yield:

: 28783-41-7
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

: 1400867-30-2
2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / acetonitrile / 70 °C

2: hydrogen bromide; dihydrogen peroxide; acetic acid / methanol / 0 - 5 °C

3: copper(l) iodide; sodium iodide; sodium methylate / Reflux

4: methyl chloroformate

5: potassium carbonate / ethanol / 0 °C

With copper(l) iodide; hydrogen bromide; dihydrogen peroxide; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; acetic acid; methyl chloroformate; sodium iodide; In methanol; ethanol; acetonitrile;
DOI:10.1016/j.tetlet.2012.07.071

Reference yield:

: 55142-78-4
5-benzyl-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine

: 1400867-30-2
2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide; dihydrogen peroxide; acetic acid / methanol / 0 - 5 °C

2: copper(l) iodide; sodium iodide; sodium methylate / Reflux

3: methyl chloroformate

4: potassium carbonate / ethanol / 0 °C

With copper(l) iodide; hydrogen bromide; dihydrogen peroxide; sodium methylate; potassium carbonate; acetic acid; methyl chloroformate; sodium iodide; In methanol; ethanol;
DOI:10.1016/j.tetlet.2012.07.071