2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Base Information

Chemical Name:2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
CAS No.:150322-60-4
Molecular Formula:C₁₉H₂₀FNO₂S
Molecular Weight:345.438
Hs Code.:

Synonyms:2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

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Chemical Property of 2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

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Technology Process of 2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

There total 10 articles about 2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1400867-30-2
2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

: 23719-80-4
cyclopropylmagnesium bromide

: 150322-60-4
2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.tetlet.2012.07.071

Reference yield: 51.2%

: 4333-56-6,130561-87-4
cyclopropyl bromide

: 2-methoxy-5-(α-methoxycarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 150322-60-4
2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Guidance literature:: cyclopropyl bromide; With iodine; magnesium; In tetrahydrofuran; for 2h; Reflux;

2-methoxy-5-(α-methoxycarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; In tetrahydrofuran; at 50 ℃; for 3h;

Reference yield:

: 28783-41-7
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

: 150322-60-4
2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / acetonitrile / 70 °C

2: hydrogen bromide; dihydrogen peroxide; acetic acid / methanol / 0 - 5 °C

3: copper(l) iodide; sodium iodide; sodium methylate / Reflux

4: methyl chloroformate

5: potassium carbonate / ethanol / 0 °C

6: tetrahydrofuran / 0 - 20 °C

With copper(l) iodide; hydrogen bromide; dihydrogen peroxide; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; acetic acid; methyl chloroformate; sodium iodide; In tetrahydrofuran; methanol; ethanol; acetonitrile; 6: |Grignard Reaction;
DOI:10.1016/j.tetlet.2012.07.071