C₂₆H₂₂F₂N₂O₂S

Base Information

• Chemical Name: C₂₆H₂₂F₂N₂O₂S
• CAS No.: 1257093-54-1
• Molecular Formula: C₂₆H₂₂F₂N₂O₂S
• Molecular Weight: 464.536
• Mol file: 1257093-54-1.mol

Synonyms:C₂₆H₂₂F₂N₂O₂S

Chemical Property of C₂₆H₂₂F₂N₂O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₂F₂N₂O₂S

There total 5 articles about C₂₆H₂₂F₂N₂O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2-fluorobenzyl)zinc(II) chloride (312693-05-3) + C19H16BrFN2O2S (1257093-53-0) → C26H22F2N2O2S (1257093-54-1)

Guidance literature:

With bis(di-tert-butyl(phenyl)phosphine) palladium dichloride; In tetrahydrofuran;

DOI:10.1021/ml100228m

Reference yield:

2-fluoro-5-bromophenyl isothiocyanate (1027513-65-0) → C26H22F2N2O2S (1257093-54-1)

Guidance literature:

Multi-step reaction with 5 steps

1: n-butyllithium / tetrahydrofuran / -78 °C

2: sodium carbonate / N,N-dimethyl-formamide / 110 °C

3: hydrogenchloride / tetrahydrofuran; water / 55 °C

4: sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane

5: bis(di-tert-butyl(phenyl)phosphine) palladium dichloride / tetrahydrofuran

With hydrogenchloride; n-butyllithium; bis(di-tert-butyl(phenyl)phosphine) palladium dichloride; sodium cyanoborohydride; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 5: Negishi coupling reaction;

DOI:10.1021/ml100228m

Reference yield:

C17H13BrFNO2S (1257093-52-9) → C26H22F2N2O2S (1257093-54-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran; water / 55 °C

2: sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane

3: bis(di-tert-butyl(phenyl)phosphine) palladium dichloride / tetrahydrofuran

With hydrogenchloride; bis(di-tert-butyl(phenyl)phosphine) palladium dichloride; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; 3: Negishi coupling reaction;

DOI:10.1021/ml100228m

upstream raw materials:

(2-fluorobenzyl)zinc(II) chloride

C₁₉H₁₆BrFN₂O₂S

2-(4-bromo-3-fluorophenyl)-1,3-dioxane

2-fluoro-5-bromophenyl isothiocyanate

Downstream raw materials:

1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid