Technology Process of 5-hexyl-2-(2-hydroxyphenoxy)phenol
There total 8 articles about 5-hexyl-2-(2-hydroxyphenoxy)phenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-hexyl-2-methoxy-1-(2-methoxyphenoxy)benzene;
With
boron tribromide;
In
dichloromethane;
at 20 ℃;
Cooling;
With
methanol;
at -40 ℃;
DOI:10.1002/cmdc.201300429
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium nitrite; sulfuric acid / water; ethanol / 0.5 h / 0 °C
1.2: 3 h / 20 °C / Reflux
2.1: boron tribromide / dichloromethane / 20 °C / Cooling
2.2: -40 °C
With
sulfuric acid; boron tribromide; sodium nitrite;
In
ethanol; dichloromethane; water;
DOI:10.1002/cmdc.201300429
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pentyltriphenylphosphonium bromide / cyclohexane; tetrahydrofuran / 0.5 h / -78 °C
1.2: 2 h / Cooling
2.1: palladium on activated charcoal; hydrogen / ethanol / 6 h / 760.05 Torr
3.1: 18-crown-6 ether; potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 - 110 °C
4.1: hydrogenchloride / water; ethanol / 0.08 h / 0 - 20 °C
5.1: sodium nitrite; sulfuric acid / water; ethanol / 0.5 h / 0 °C
5.2: 3 h / 20 °C / Reflux
6.1: boron tribromide / dichloromethane / 20 °C / Cooling
6.2: -40 °C
With
hydrogenchloride; 18-crown-6 ether; sulfuric acid; palladium on activated charcoal; pentyltriphenylphosphonium bromide; hydrogen; boron tribromide; potassium carbonate; sodium nitrite;
In
tetrahydrofuran; ethanol; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300429
