1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole

Base Information

Chemical Name:1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole
CAS No.:1056265-71-4
Molecular Formula:C₂₇H₂₀F₂N₂O₂
Molecular Weight:442.465
Hs Code.:

Synonyms:1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole

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Chemical Property of 1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole

Chemical Property:

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Technology Process of 1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole

There total 3 articles about 1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 156635-88-0
4-benzyloxy-3,5-difluorophenylboronic acid

: 850364-08-8
4-(benzyloxy)-1H-indazole

: 1056265-71-4
1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole

Guidance literature:: With pyridine; copper diacetate; In dichloromethane; at 20 ℃; for 120h; Molecular sieve;

Reference yield:

: 100-39-0
benzyl bromide

: 1056265-71-4
1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 2 h / 20 °C

2.1: pyridine / copper diacetate / dichloromethane / 120 h / 20 °C / Molecular sieve

With pyridine; sodium hydride; copper diacetate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 81382-45-8
4-hydroxyindazole

: 1056265-71-4
1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 2 h / 20 °C

2.1: pyridine / copper diacetate / dichloromethane / 120 h / 20 °C / Molecular sieve

With pyridine; sodium hydride; copper diacetate; In dichloromethane; N,N-dimethyl-formamide;