2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene

Base Information

Chemical Name:2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene
CAS No.:849347-00-8
Molecular Formula:C₂₁H₂₂O₂S
Molecular Weight:338.47
Hs Code.:

Synonyms:2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene

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Chemical Property of 2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene

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Technology Process of 2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene

There total 1 articles about 2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 487-68-3
mesytaldehyde

: 596104-73-3
2-[1-phenyl-1-(tert-butyldimethylsilyloxy)methyl]thiophene

: 849347-00-8
2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene

Guidance literature:: 2-[1-phenyl-1-(tert-butyldimethylsilyloxy)methyl]thiophene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; for 0.5h;

mesytaldehyde; In tetrahydrofuran; hexane; at 0 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;
DOI:10.1016/j.bmc.2004.12.048

Reference yield: 78.0%

: 849347-00-8
2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene

: 109-97-7,30604-81-0
pyrrole

: 849347-01-9
2-[phenyl(pyrrolo)methyl]-5-[pyrrolo(2,4,6-trimethylphenyl)methyl]thiophene

Guidance literature:: With boron trifluoride diethyl etherate; for 1h;
DOI:10.1016/j.bmc.2004.12.048

Reference yield:

: 849347-00-8
2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene

: 5-phenyl-20-(2,4,6-trimethylphenyl)-10,15-bis[4-(carboxymethoxy)phenyl]-21,23-dithiaporphyrin

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / BF₃*OEt₂ / 1 h

2: 13 percent / 2,3,5,6-tetrachlorobenzoquinone; p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 0.5 h

3: 90 percent / aq. NaOH / tetrahydrofuran / 15 h

With sodium hydroxide; boron trifluoride diethyl etherate; chloranil; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2004.12.048