Silane, (1,1-dimethylethyl)dimethyl(phenyl-2-thienylmethoxy)-

Base Information

• Chemical Name: Silane, (1,1-dimethylethyl)dimethyl(phenyl-2-thienylmethoxy)-
• CAS No.: 596104-73-3
• Molecular Formula: C17H24OSSi
• Molecular Weight: 304.528
• DSSTox Substance ID: DTXSID40450222
• Mol file: 596104-73-3.mol

Synonyms:596104-73-3;Silane, (1,1-dimethylethyl)dimethyl(phenyl-2-thienylmethoxy)-;DTXSID40450222

Chemical Property of Silane, (1,1-dimethylethyl)dimethyl(phenyl-2-thienylmethoxy)-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 304.13171309
• Heavy Atom Count: 20
• Complexity: 305

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OC(C1=CC=CC=C1)C2=CC=CS2

Technology Process of Silane, (1,1-dimethylethyl)dimethyl(phenyl-2-thienylmethoxy)-

There total 2 articles about Silane, (1,1-dimethylethyl)dimethyl(phenyl-2-thienylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

phenyl-thiophen-2-yl-methanol (26059-21-2,105748-50-3,118759-49-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 2-[1-phenyl-1-(tert-butyldimethylsilyloxy)methyl]thiophene (596104-73-3)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 26h;

DOI:10.1021/jm030136i

Reference yield:

benzaldehyde (100-52-7) → 2-[1-phenyl-1-(tert-butyldimethylsilyloxy)methyl]thiophene (596104-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / hexane

1.2: hexane; tetrahydrofuran / cooling

2.1: Et₃N; DMAP

With dmap; n-butyllithium; triethylamine; In hexane;

DOI:10.1016/j.bmc.2005.07.006

Reference yield: 73.0%

thiophene-2-carbaldehyde (98-03-3) + 2-[1-phenyl-1-(tert-butyldimethylsilyloxy)methyl]thiophene (596104-73-3) → 2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene (849346-90-3)

Guidance literature:

2-[1-phenyl-1-(tert-butyldimethylsilyloxy)methyl]thiophene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; for 0.5h;

thiophene-2-carbaldehyde; In tetrahydrofuran; hexane; at 0 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;

DOI:10.1016/j.bmc.2004.12.048

upstream raw materials:

phenyl-thiophen-2-yl-methanol

tert-butyldimethylsilyl chloride

benzaldehyde

Downstream raw materials:

2-[1-(4-methoxyphenyl)-1-hydroxymethyl]-5-(1-phenyl-1-hydroxymethyl)thiophene

2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene

2-[hydroxy(phenyl)methyl]-5-[hydroxy(2,4,6-trimethylphenyl)methyl]thiophene

2-[(4-tert-butylphenyl)(hydroxy)methyl]-5-[hydroxy(phenyl)methyl]thiophene