methyl 4-(1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl)benzoate

Base Information

• Chemical Name: methyl 4-(1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl)benzoate
• CAS No.: 1050656-33-1
• Molecular Formula: C₂₈H₂₃F₃N₂O₃
• Molecular Weight: 492.497
• Mol file: 1050656-33-1.mol

Synonyms:methyl 4-(1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl)benzoate

Chemical Property of methyl 4-(1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl)benzoate

There total 5 articles about methyl 4-(1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(1-aminocyclopropyl)-benzoic acid methyl ester (1006037-03-1) + C6H15N*C17H12F3NO2 (1252610-01-7) → methyl 4-(1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl)benzoate (1050656-33-1)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

4-(1-aminocyclopropyl)-benzoic acid methyl ester (1006037-03-1) + 1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxylic acid (1050656-31-9) → methyl 4-(1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl)benzoate (1050656-33-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

4-cyanobenzoic acid methyl ester (1129-35-7) → methyl 4-(1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl)benzoate (1050656-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium(IV) isopropylate / tetrahydrofuran; toluene / 2.5 h / -25 °C

1.2: 1.33 h / -25 °C

1.3: -25 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; titanium(IV) isopropylate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-(1-aminocyclopropyl)-benzoic acid methyl ester

1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxylic acid

C₆H₁₅N*C₁₇H₁₂F₃NO₂

1-(4-trifluoromethyl-benzyl)-1H-indole-7-carboxylic acid methyl ester

Downstream raw materials:

MF-766