tert-butyl 3-cyclohexyl-2-(4-fluoro-2-formylphenyl)-1H-indole-6-carboxylate

Base Information

Chemical Name:tert-butyl 3-cyclohexyl-2-(4-fluoro-2-formylphenyl)-1H-indole-6-carboxylate
CAS No.:1204417-92-4
Molecular Formula:C₂₆H₂₈FNO₃
Molecular Weight:421.512
Hs Code.:

Synonyms:tert-butyl 3-cyclohexyl-2-(4-fluoro-2-formylphenyl)-1H-indole-6-carboxylate

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Chemical Property of tert-butyl 3-cyclohexyl-2-(4-fluoro-2-formylphenyl)-1H-indole-6-carboxylate

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Technology Process of tert-butyl 3-cyclohexyl-2-(4-fluoro-2-formylphenyl)-1H-indole-6-carboxylate

There total 2 articles about tert-butyl 3-cyclohexyl-2-(4-fluoro-2-formylphenyl)-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1204417-91-3
tert-butyl 3-cyclohexyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-6-carboxylate

: 94569-84-3
2-bromo-5-fluorobenzaldehyde

: 1204417-92-4
tert-butyl 3-cyclohexyl-2-(4-fluoro-2-formylphenyl)-1H-indole-6-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 20 - 70 ℃; Inert atmosphere;

Reference yield:

: 825644-26-6
(4-fluoro-2-formylphenyl)boronic acid

: 879498-90-5
1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester

: 1204417-92-4
tert-butyl 3-cyclohexyl-2-(4-fluoro-2-formylphenyl)-1H-indole-6-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 70 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.04.113

Reference yield:

: 1204417-92-4
tert-butyl 3-cyclohexyl-2-(4-fluoro-2-formylphenyl)-1H-indole-6-carboxylate

: 1204417-14-0
C₃₁H₃₅FN₄O₅S

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / N,N-dimethyl-formamide / 60 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran

4: sulfonamide / 1,2-dioxacyclohexane / 100 °C

5: trifluoroacetic acid / dichloromethane

6: tetrahydrofuran / 20 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran

With sulfonamide; water; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,2-dioxacyclohexane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.04.113