Proflavine

Base Information

• Chemical Name: Proflavine
• CAS No.: 92-62-6
• Molecular Formula: C13H11 N3
• Molecular Weight: 209.25
• Hs Code.: 2933990090
• European Community (EC) Number: 202-172-4,217-320-3
• UNII: CY3RNB3K4T
• DSSTox Substance ID: DTXSID9043776
• Nikkaji Number: J3.930F
• Wikipedia: Proflavine
• Wikidata: Q420454
• NCI Thesaurus Code: C77055
• RXCUI: 8723
• Metabolomics Workbench ID: 43348
• ChEMBL ID: CHEMBL55400
• Mol file: 92-62-6.mol

Synonyms:3,6 Diamino Acridine;3,6 Diaminoacridine;3,6-diamino acridine;3,6-diaminoacridine;Acridine, 3,6-Diamino;Hemisulfate, Proflavine;Proflavin;Proflavine;Proflavine Hemisulfate

Chemical Property of Proflavine

Chemical Property:

• Appearance/Colour: orange to brown powder
• Vapor Pressure: 3.91E-10mmHg at 25°C
• Melting Point: 260 C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 506.9 °C at 760 mmHg
• PKA: 9.65(at 20℃)
• Flash Point: 292.9 °C
• PSA: 64.93000
• Density: 1.346 g/cm³
• LogP: 3.71480
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 209.095297364
• Heavy Atom Count: 16
• Complexity: 232

Purity/Quality:

99%, ^*data from raw suppliers

Acridine-3,6-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 9 (Packing Group: III) UN NO.
• Hazard Codes: 9 (Packing Group: III) UN NO.

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Uses -> Biocides/Disinfectants
• Canonical SMILES: C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N
• Recent ClinicalTrials: Precision Optical Guidance for Oral Biopsy

Technology Process of Proflavine

There total 20 articles about Proflavine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

proflavine hydrochloride (952-23-8) → proflavine (92-62-6)

Guidance literature:

With sodium hydrogencarbonate; In water; at 40 ℃; pH=10;

Reference yield:

m-phenylenediamine (108-45-2,64554-26-3,76583-20-5) → proflavine (92-62-6)

Guidance literature:

With oxalic acid; zinc(II) chloride; at 190 ℃; Glycerin;

DOI:10.1039/jr9410000121

Reference yield:

acridine orange (248928-58-7) → proflavine (92-62-6)

Guidance literature:

With zinc(II) oxide; squaraine; protoporphyrin IX; In water; for 1h; Reagent/catalyst; Irradiation;

DOI:10.1039/c7cp08431e

upstream raw materials:

formic acid

m-phenylenediamine dihydrochloride

3,6-diaminoacridin-9(10H)-one

4,4'-methylenebis(m-nitroaniline)

Downstream raw materials:

N³,N⁶-bis-(4-methoxy-benzyliden)-acridine-3,6-diyldiamine

acridin-3-ylamine

dihydroxy-3,6 acridine

3,6-Diamino-4-(4-nitro-phenylazo)acridin

Refernces

• 1、 Patwari, Jayita,Chatterjee, Arka,Sardar, Samim,Lemmens, Peter,Pal, Samir Kumar. "Ultrafast dynamics in co-sensitized photocatalysts under visible and NIR light irradiation". . p. 10418 - 10429. Retrieved 2018/04/27.