Products Categories
| CAS No.: | 92-62-6 |
|---|---|
| Name: | PROFLAVINE |
| Article Data: | 16 |
| Molecular Structure: | |
|
|
|
| Formula: | C13H11 N3 |
| Molecular Weight: | 209.25 |
| Synonyms: | Acridine,3,6-diamino- (8CI); 3,6-Diaminoacridine; 3,7-Diamino-5-azaanthracene; Isoflavbase; Proflavin; Proflavine |
| EINECS: | 202-172-4 (Proflavine) |
| Density: | 1.346 g/cm3 |
| Melting Point: | 260 C |
| Boiling Point: | 506.9 °C at 760 mmHg |
| Flash Point: | 292.9 °C |
| Solubility: | Slightly soluble SOLVENT |
| Appearance: | orange to brown powder |
| Hazard Symbols: | 9 (Packing Group: III) UN NO. |
| Safety: | Poison by intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also 2,6-DIAMINOACRIDINE; 3,6-DIAMINOACRIDINE HYDROCHLORIDE HEMIHYDRATE; 3,6-DIAMINOACRIDINE SULFATE (1:1). |
| Transport Information: | 307 |
| PSA: | 64.93000 |
| LogP: | 3.71480 |
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
- 926293-55-26-Bromo-2-methylpyridine-3-carboxaldehyde
- 95789-13-21,3,7-trimethylpurine-2,6-dione
- 956104-42-02-Bromo-5-nitro-3-(trifluoromethyl)pyridine
- 945683-37-41-butyl-2,3-dimethylimidazolium octanesulfate
- 946052-36-41-Butyl-3-methylpyridinium methanesulfonate
- 942196-38-51-Hexyl-3-methylpyridinium hexafluorophosphat
- 929897-32-51-hexyl-4-methylpridine hexafluorophosphate
| Conditions | Yield |
|---|---|
| With glycerol at 155℃; |
- 42832-87-1
3,6-diaminoacridin-9(10H)-one
- 92-62-6
proflavine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; sodium amalgam; water |
- 26946-33-8
4,4'-methylenebis(m-nitroaniline)
- 92-62-6
proflavine
| Conditions | Yield |
|---|---|
| With hydrogenchloride; tin at 135 - 140℃; |
- 181189-62-8
4,4'-methanediyl-bis-m-phenylenediamine
- 92-62-6
proflavine
| Conditions | Yield |
|---|---|
| With hydrogenchloride at 170℃; |
- 144-62-7
oxalic acid
- 108-45-2
m-phenylenediamine
- 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester
- 56-81-5
glycerol
- 92-62-6
proflavine
| Conditions | Yield |
|---|---|
| at 190℃; |
- 64-18-6
formic acid
- 108-45-2
m-phenylenediamine
- 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester
- 56-81-5
glycerol
- 92-62-6
proflavine
| Conditions | Yield |
|---|---|
| at 190℃; |
| Conditions | Yield |
|---|---|
| With oxalic acid; zinc(II) chloride at 190℃; Glycerin; | |
| With formic acid; zinc(II) chloride at 190℃; Glycerin; |
| Conditions | Yield |
|---|---|
| at 155℃; |
- 6262-24-4
formic acid-(3-amino-anilide)
- 541-69-5
m-phenylenediamine dihydrochloride
- 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester
- 56-81-5
glycerol
- 92-62-6
proflavine
| Conditions | Yield |
|---|---|
| at 155℃; |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; formic acid; water |
- Total:12 Page 1 of 1 1
What can I do for you?
Get Best Price
Chemistry
Chemistry informtion about Proflavine (CAS NO.92-62-6) is:
IUPAC Name: Acridine-3,6-Diamine
Synonyms: Proflavine ; 3,6-Acridinediamine ; 3,6-Aiaminoacridine ; Isoflabase
MF: C13H11N3
MW: 11209.2465
Density: 1.346 g/cm3
Flash Point: 292.9 °C
Boiling Point: 506.9 °C at 760 mmHg
Vapour Pressure: 2.14E-10 mmHg at 25°C
Enthalpy of Vaporization: 77.69 kJ/mol
Following is the molecular structure of Proflavine (CAS NO.92-62-6) is:
Uses
3,6-Diaminoacridinium (CAS NO.92-62-6) has been used in the form of the dihydrochloride and hemisulfate salts as a topical antiseptic, and was formerly used as a urinary antiseptic.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 11111ug/kg (11.111mg/kg) | sense organs and special senses: other changes: olfaction sense organs and special senses: other: eye lungs, thorax, or respiration: other changes | Lancet. Vol. 196, Pg. 838, 1919. |
| mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | Chemotherapy Vol. 16, Pg. 371, 1971. | |
| mouse | LD50 | oral | > 1gm/kg (1000mg/kg) | Journal of Medicinal Chemistry. Vol. 18, Pg. 320, 1975. | |
| mouse | LD50 | subcutaneous | 140mg/kg (140mg/kg) | British Journal of Experimental Pathology. Vol. 28, Pg. 1, 1947. |
Consensus Reports
IARC Cancer Review: Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 (1980),p. 195.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
Poison by intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also 2,6-DIAMINOACRIDINE; 3,6-DIAMINOACRIDINE HYDROCHLORIDE HEMIHYDRATE; 3,6-DIAMINOACRIDINE SULFATE (1:1).
Specification
Proflavine (CAS NO.92-62-6), also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acid base pairs. It differs from most other mutagenic components by causing basepair-deletions or basepair-insertions and not substitutions. Proflavine absorbs strongly in the blue region at 445nm (in water at pH 7) with molar extinction coefficient of c. 40,000.