3-{3-((5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)propanyl}-(4S)-methyl-(5R)-phenyl-1,3-oxazolidin-2-one

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Chemical Name:3-{3-((5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)propanyl}-(4S)-methyl-(5R)-phenyl-1,3-oxazolidin-2-one
CAS No.:912917-36-3
Molecular Formula:C₃₀H₂₇F₂N₃O₄
Molecular Weight:531.559
Hs Code.:

Synonyms:3-{3-((5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)propanyl}-(4S)-methyl-(5R)-phenyl-1,3-oxazolidin-2-one

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Chemical Property of 3-{3-((5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)propanyl}-(4S)-methyl-(5R)-phenyl-1,3-oxazolidin-2-one

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Technology Process of 3-{3-((5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)propanyl}-(4S)-methyl-(5R)-phenyl-1,3-oxazolidin-2-one

There total 5 articles about 3-{3-((5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)propanyl}-(4S)-methyl-(5R)-phenyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₇ClF₂N₂O₂

: 912917-36-3
3-{3-((5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)propanyl}-(4S)-methyl-(5R)-phenyl-1,3-oxazolidin-2-one

Guidance literature:: (4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

C₂₀H₁₇ClF₂N₂O₂; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

Reference yield:

: C₂₅H₂₈F₂N₂O₃

: 912917-36-3
3-{3-((5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)propanyl}-(4S)-methyl-(5R)-phenyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C

2.1: methanol; ethanol; hexane; diethylamine / Resolution of racemate

3.1: periodic acid / water; acetonitrile / 0 °C

4.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: 1.5 h / -78 °C

With n-butyllithium; thionyl chloride; toluene-4-sulfonic acid; periodic acid; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; diethylamine; acetonitrile;

Reference yield:

: 873805-95-9
3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]propan-1-ol

: 912917-36-3
3-{3-((5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)propanyl}-(4S)-methyl-(5R)-phenyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: periodic acid / water; acetonitrile / 0 °C

2.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 1.5 h / -78 °C

With n-butyllithium; thionyl chloride; periodic acid; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;