3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-propanoic acid

Base Information

Chemical Name:3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-propanoic acid
CAS No.:912917-35-2
Molecular Formula:C₂₀H₁₈F₂N₂O₃
Molecular Weight:372.371
Hs Code.:

Synonyms:3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-propanoic acid

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Chemical Property of 3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-propanoic acid

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Technology Process of 3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-propanoic acid

There total 3 articles about 3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873805-95-9
3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]propan-1-ol

: 912917-35-2
3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-propanoic acid

Guidance literature:: With periodic acid; In water; acetonitrile; at 0 ℃;

Reference yield:

: 873814-86-9
3-[1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]propan-1-ol

: 912917-35-2
3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; ethanol; hexane; diethylamine / Resolution of racemate

2: periodic acid / water; acetonitrile / 0 °C

With periodic acid; In methanol; ethanol; hexane; water; diethylamine; acetonitrile;

Reference yield:

: C₂₅H₂₈F₂N₂O₃

: 912917-35-2
3-[(5S)-1-acetyl-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C

2: methanol; ethanol; hexane; diethylamine / Resolution of racemate

3: periodic acid / water; acetonitrile / 0 °C

With toluene-4-sulfonic acid; periodic acid; In methanol; ethanol; hexane; water; diethylamine; acetonitrile;