2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate

Base Information

• Chemical Name: 2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate
• CAS No.: 1448451-00-0
• Molecular Formula: C₁₄H₁₆O₄
• Molecular Weight: 248.279
• Mol file: 1448451-00-0.mol

Synonyms:2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate

Chemical Property of 2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate

There total 1 articles about 2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

methyl propargyl alcohol (764-01-2) + 2-(4-hydroxyphenyl)ethyl acetate (58556-55-1) → 2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate (1448451-00-0)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; at 0 - 20 ℃;

DOI:10.1002/anie.201300137

Reference yield: 81.0%

2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate (1448451-00-0) + 4-methoxyphenylboronic acid (5720-07-0) → 2-((3aS,7aS,E)-3-(1-(4-methoxyphenyl)ethylidene)-5-oxo-2,3,3a,4,5,7a-hexahydrobenzofuran-7a-yl)ethyl acetate

Guidance literature:

4-methoxyphenylboronic acid; With potassium hydrogenfluoride; chlorobis(ethylene)rhodium(I) dimer; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;

2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate; With water; In toluene; at 60 ℃; for 17h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201300137

Reference yield: 80.0%

2-(1-(but-2-yn-1-yloxy)-4-oxocyclohexa-2,5-dien-1-yl)ethyl acetate (1448451-00-0) + phenylacetylene (536-74-3) → C22H22O4

Guidance literature:

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); In 1,2-dichloro-ethane; at 40 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201911071

upstream raw materials:

methyl propargyl alcohol

2-(4-hydroxyphenyl)ethyl acetate