2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol

Base Information

• Chemical Name: 2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol
• CAS No.: 1394289-91-8
• Molecular Formula: C₂₆H₂₀Br₂N₆O₂
• Molecular Weight: 608.292
• Mol file: 1394289-91-8.mol

Synonyms:2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol

Chemical Property of 2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol

There total 4 articles about 2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

C25H19Br2N3O3 (1394289-63-4) + guanidine hydrochloride (50-01-1) → 2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol (1394289-91-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 100 ℃;

DOI:10.1016/j.bmc.2012.07.009

Reference yield:

C18H16BrN3O3 (1394289-44-1) → 2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol (1394289-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 4 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 - 100 °C

With sodium hydride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; 1: |Claisen-Schmidt Condensation;

DOI:10.1016/j.bmc.2012.07.009

Reference yield:

1-(2-hydroxy-4-prop-2-ynyloxy-phenyl)-ethanone (67091-10-5) → 2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol (1394289-91-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 4 h / 20 °C

2: potassium hydroxide / ethanol / 4 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 0 - 100 °C

With copper(ll) sulfate pentahydrate; sodium hydride; sodium L-ascorbate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 2: |Claisen-Schmidt Condensation;

DOI:10.1016/j.bmc.2012.07.009

upstream raw materials:

C₁₈H₁₆BrN₃O₃

1-(2-hydroxy-4-prop-2-ynyloxy-phenyl)-ethanone

2',4'-dihydroxy-4-acetophenone

C₂₅H₁₉Br₂N₃O₃