(6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)boronic acid

Base Information

Chemical Name:(6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)boronic acid
CAS No.:1340593-79-4
Molecular Formula:C₁₄H₁₀BF₄NO₃
Molecular Weight:327.043
Hs Code.:

Synonyms:(6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)boronic acid

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Chemical Property of (6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)boronic acid

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Technology Process of (6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)boronic acid

There total 4 articles about (6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 121-43-7,63156-11-6
Trimethyl borate

: 294182-28-8
5-bromo-2-((-2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridine

: 1340593-79-4
(6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)boronic acid

Guidance literature:: 5-bromo-2-((-2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

Trimethyl borate; at -78 ℃; for 0.166667h; Inert atmosphere;

With water; acetic acid; In diethyl ether; hexane; at 20 ℃; for 1h;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1340593-79-4
(6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether / 3 h / -70 - 20 °C

2.1: diethyl ether / 2 h / 0 - 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C

3.2: 0.17 h / -78 °C / Inert atmosphere

3.3: 1 h / 20 °C

With n-butyllithium; In diethyl ether; hexane;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1340593-79-4
(6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / diethyl ether / 3 h / -70 - 20 °C

3.1: diethyl ether / 2 h / 0 - 20 °C

4.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C

4.2: 0.17 h / -78 °C / Inert atmosphere

4.3: 1 h / 20 °C

With n-butyllithium; copper; In diethyl ether; hexane; dimethyl sulfoxide;