(1S,2R)-2-(Pyrrolidin-1-yl)cyclohexan-1-amine

Base Information

Chemical Name:(1S,2R)-2-(Pyrrolidin-1-yl)cyclohexan-1-amine
CAS No.:133575-75-4
Molecular Formula:C₁₀H₂₀N₂
Molecular Weight:168.282
Hs Code.:
DSSTox Substance ID:DTXSID60559261
Wikidata:Q82441923

Synonyms:(1S,2R)-2-(Pyrrolidin-1-yl)cyclohexan-1-amine;133575-75-4;SCHEMBL6909004;DTXSID60559261

Suppliers and Price of (1S,2R)-2-(Pyrrolidin-1-yl)cyclohexan-1-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-2-(Pyrrolidin-1-yl)cyclohexan-1-amine

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:168.162648646
Heavy Atom Count:12
Complexity:141

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCC(C(C1)N)N2CCCC2
Isomeric SMILES:C1CC[C@H]([C@H](C1)N)N2CCCC2

Technology Process of (1S,2R)-2-(Pyrrolidin-1-yl)cyclohexan-1-amine

There total 11 articles about (1S,2R)-2-(Pyrrolidin-1-yl)cyclohexan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 133575-75-4
(+)-cis-2-(1-pyrrolidinyl)cyclohexylamine

Guidance literature:

Reference yield: 50.0%

: 123-75-1
pyrrolidine

: 286-18-0
7-azabicyclo[4.1.0]heptane

: 26785-37-5,116274-91-0,118768-63-1,121211-87-8,133488-96-7,133575-74-3,133575-75-4
(+/-)-trans-2-(pyrrolidin-1-yl)cyclohexanamine

Guidance literature:: With ammonium chloride; In water; at 110 ℃; for 16h;
DOI:10.1002/jps.2600790821

Reference yield:

: 931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5,931-15-7
(+/-)-trans-2-aminocyclohexanol

: 133575-75-4
(+)-cis-2-(1-pyrrolidinyl)cyclohexylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / sodium bicarbonate / CHCl₃; H₂O / 1 h

2: 86 percent / Jones reagent (CrO₃, conc. H₂SO₄, H₂O) / acetone / 1 h

3: 1.) p-toluenesulfonic acid, 2.) H₂ / 2.) 10percent Pd/C / 1.) benzene, reflux, 23 h, 2.) ethyl acetate, 50 p.s.i, RT, 1.5 h

4: 95.6 percent / KOH / ethane-1,2-diol / 48 h / Heating

With potassium hydroxide; Jones reagent (CrO₃, conc. H₂SO₄, H₂O); hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In chloroform; water; ethylene glycol; acetone;