C₂₈H₁₈ClN₅O

Base Information

Chemical Name:C₂₈H₁₈ClN₅O
CAS No.:1600565-79-4
Molecular Formula:C₂₈H₁₈ClN₅O
Molecular Weight:475.937
Hs Code.:

C<sub>28</sub>H<sub>18</sub>ClN<sub>5</sub>O

Synonyms:C₂₈H₁₈ClN₅O

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Chemical Property of C₂₈H₁₈ClN₅O

Chemical Property:

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Technology Process of C₂₈H₁₈ClN₅O

There total 12 articles about C₂₈H₁₈ClN₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1600565-78-3
6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile

: 1600565-79-4
C₂₈H₁₈ClN₅O

: 1600565-80-7
C₂₈H₁₈ClN₅O

Guidance literature:: With chiral HPLC (Chiralpak AD, 100percent EtOH); In ethanol; Resolution of racemate;

Reference yield:

: 452349-62-1
methyl 5-bromo-2-(2-phenylacetamido)benzoate

: 1600565-79-4
C₂₈H₁₈ClN₅O

: 1600565-80-7
C₂₈H₁₈ClN₅O

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane; water / 4 h / -78 - 20 °C

2.1: trichlorophosphate / 3.5 h / 107 °C

3.1: n-butyllithium / tetrahydrofuran / 1.67 h / 20 °C / Inert atmosphere; Cooling with acetone-dry ice

3.2: Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 22 h / 120 °C / Sealed tube; Inert atmosphere

5.1: chiral HPLC (Chiralpak AD, 100percent EtOH) / ethanol / Resolution of racemate

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; lithium hexamethyldisilazane; zinc; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl acetamide; water;

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 1600565-79-4
C₂₈H₁₈ClN₅O

: 1600565-80-7
C₂₈H₁₈ClN₅O

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 72 h / 20 °C

2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.33 h / Inert atmosphere; Cooling with ice

2.2: 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / 1.67 h / 20 °C / Inert atmosphere; Cooling with acetone-dry ice

3.2: Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 22 h / 120 °C / Sealed tube; Inert atmosphere

5.1: chiral HPLC (Chiralpak AD, 100percent EtOH) / ethanol / Resolution of racemate

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; ethylmagnesium bromide; zinc; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl acetamide;