dimethyl 2-(3-phenyl-2-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-4-yl)malonate

Base Information

Chemical Name:dimethyl 2-(3-phenyl-2-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-4-yl)malonate
CAS No.:1440513-66-5
Molecular Formula:C₂₆H₂₁F₃N₂O₄
Molecular Weight:482.459
Hs Code.:

Synonyms:dimethyl 2-(3-phenyl-2-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-4-yl)malonate

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Chemical Property of dimethyl 2-(3-phenyl-2-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-4-yl)malonate

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Technology Process of dimethyl 2-(3-phenyl-2-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-4-yl)malonate

There total 4 articles about dimethyl 2-(3-phenyl-2-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-4-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 20887-06-3
N-(2-aminobenzyl)aniline

: 108-59-8
malonic acid dimethyl ester

: 1440513-66-5
dimethyl 2-(3-phenyl-2-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-4-yl)malonate

Guidance literature:: 4-Trifluoromethylbenzaldehyde; N-(2-aminobenzyl)aniline; In ethanol; at 20 ℃; for 3h;

With tert.-butylhydroperoxide; potassium iodide; In ethanol; water; at 20 ℃;

malonic acid dimethyl ester; In acetonitrile; at 50 ℃; for 24h;
DOI:10.1002/adsc.201200679

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 1440513-66-5
dimethyl 2-(3-phenyl-2-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-4-yl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzene / 5 h / Reflux

1.2: 20 °C

2.1: hydrogen; platinum(IV) oxide / ethanol

3.1: ethanol / 3 h / 20 °C

3.2: 20 °C

3.3: 24 h / 50 °C

With platinum(IV) oxide; hydrogen; In ethanol; benzene;
DOI:10.1002/adsc.201200679

Reference yield:

: 62-53-3
aniline

: 1440513-66-5
dimethyl 2-(3-phenyl-2-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-4-yl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzene / 5 h / Reflux

1.2: 20 °C

2.1: hydrogen; platinum(IV) oxide / ethanol

3.1: ethanol / 3 h / 20 °C

3.2: 20 °C

3.3: 24 h / 50 °C

With platinum(IV) oxide; hydrogen; In ethanol; benzene;
DOI:10.1002/adsc.201200679