2-(triphenylmethyl)-5-<(4'-<(butylamino)methyl>biphenyl-2-yl)>-2H-tetrazole

Base Information

• Chemical Name: 2-(triphenylmethyl)-5-<(4'-<(butylamino)methyl>biphenyl-2-yl)>-2H-tetrazole
• CAS No.: 143618-46-6
• Molecular Formula: C₃₇H₃₅N₅
• Molecular Weight: 549.718

Synonyms:2-(triphenylmethyl)-5-<(4'-<(butylamino)methyl>biphenyl-2-yl)>-2H-tetrazole

Chemical Property of 2-(triphenylmethyl)-5-<(4'-<(butylamino)methyl>biphenyl-2-yl)>-2H-tetrazole

Chemical Property:

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Technology Process of 2-(triphenylmethyl)-5-<(4'-<(butylamino)methyl>biphenyl-2-yl)>-2H-tetrazole

There total 1 articles about 2-(triphenylmethyl)-5-<(4'-<(butylamino)methyl>biphenyl-2-yl)>-2H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole (133051-88-4) + N-butylamine (109-73-9,85404-21-3) → 2-(triphenylmethyl)-5-<(4'-<(butylamino)methyl>biphenyl-2-yl)>-2H-tetrazole (143618-46-6)

Guidance literature:

In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1021/jm00098a018

Reference yield: 78.0%

2-(triphenylmethyl)-5-<(4'-<(butylamino)methyl>biphenyl-2-yl)>-2H-tetrazole (143618-46-6) + ethyl 3,6-dichloropyridazine-4-carboxylate (34127-22-5) → ethyl 3-biphenyl-4-yl>methyl>amino>-6-chloropyridazine-4-carboxylate (151322-61-1)

Guidance literature:

With triethylamine; Heating;

DOI:10.1021/jm00070a012

Reference yield: 70.0%

3-bromo-pyrazine-2-carboxylic acid methyl ester (51171-02-9) + 2-(triphenylmethyl)-5-<(4'-<(butylamino)methyl>biphenyl-2-yl)>-2H-tetrazole (143618-46-6) → methyl 3-biphenyl-4-yl>methyl>amino>pyrazine-2-carboxylate (151322-82-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jm00070a012

upstream raw materials:

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

N-butylamine

Downstream raw materials:

methyl 3-biphenyl-4-yl>methyl>amino>pyrazine-2-carboxylate

4-{Butyl-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2-methyl-pyrimidine-5-carboxylic acid ethyl ester

2-{Butyl-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-nicotinic acid ethyl ester

2-{Butyl-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-6-methyl-nicotinic acid ethyl ester

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