2-bromoethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

Base Information

Chemical Name:2-bromoethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate
CAS No.:1285548-84-6
Molecular Formula:C₂₆H₃₉BrClN₃O₆
Molecular Weight:604.969
Hs Code.:

Synonyms:2-bromoethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

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Chemical Property of 2-bromoethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

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Technology Process of 2-bromoethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

There total 10 articles about 2-bromoethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202400-18-7
1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-(2-hydroxy-2-methylpropyl)urea

: 4801-27-8
2-bromoethyl chloroformate

: 1285548-84-6
2-bromoethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 324769-06-4
tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

: 1285548-84-6
2-bromoethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - -60 °C

1.2: 2 h / -78 - -60 °C

2.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

3.1: butanone; water / 20 °C / Reflux

4.1: sodium hydroxide / water

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

5.2: 20 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

7.2: 1 h

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

9.1: pyridine / dichloromethane / 4 h / 0 - 20 °C

With pyridine; hydrogenchloride; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; benzotriazol-1-ol; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; acetonitrile; butanone;

Reference yield:

: 690660-21-0
4-(4-chloro-phenyl)-3,3-dimethyl-piperidin-4-ol

: 1285548-84-6
2-bromoethyl 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl carbonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: butanone; water / 20 °C / Reflux

2.1: sodium hydroxide / water

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

3.2: 20 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5.2: 1 h

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

7.1: pyridine / dichloromethane / 4 h / 0 - 20 °C

With pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; benzotriazol-1-ol; In 1,4-dioxane; dichloromethane; water; acetonitrile; butanone;