CCR1 antagonist 2

Base Information

Chemical Name:CCR1 antagonist 2
CAS No.:1202400-18-7
Molecular Formula:C₂₃H₃₆ClN₃O₄
Molecular Weight:454.01
Hs Code.:
Mol file:1202400-18-7.mol

Synonyms:Urea, N-[(1R)-1-[[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-1-piperidinyl]carbonyl]-2-methylpropyl]-N'-(2-hydroxy-2-methylpropyl)-;

Suppliers and Price of CCR1 antagonist 2

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of CCR1 antagonist 2

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of CCR1 antagonist 2

There total 9 articles about CCR1 antagonist 2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 946589-86-2
phenyl (R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1202400-18-7
1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-(2-hydroxy-2-methylpropyl)urea

Guidance literature:: With triethylamine; In acetonitrile; at 100 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;
DOI:10.1021/jm5003167

Reference yield:

: 690660-22-1
(S)-4-(4-chlorophenyl)-3,3-dimethylpiperidin-4-ol

: 1202400-18-7
1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-(2-hydroxy-2-methylpropyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

1.2: 20 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.2: 1 h

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 690660-21-0
4-(4-chloro-phenyl)-3,3-dimethyl-piperidin-4-ol

: 1202400-18-7
1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-(2-hydroxy-2-methylpropyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: butanone; water / 20 °C / Reflux

2.1: sodium hydroxide / water

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

3.2: 20 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5.2: 1 h

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; benzotriazol-1-ol; In 1,4-dioxane; dichloromethane; water; acetonitrile; butanone;