(S)-5-((diphenylphosphino)methyl)-3,3-bis[1-(2,4,6-trimethylphenyl)methyl]pyrrolidin-2-one

Base Information

Chemical Name:(S)-5-((diphenylphosphino)methyl)-3,3-bis[1-(2,4,6-trimethylphenyl)methyl]pyrrolidin-2-one
CAS No.:627503-60-0
Molecular Formula:C₃₇H₄₂NOP
Molecular Weight:547.72
Hs Code.:

Synonyms:(S)-5-((diphenylphosphino)methyl)-3,3-bis[1-(2,4,6-trimethylphenyl)methyl]pyrrolidin-2-one

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Chemical Property of (S)-5-((diphenylphosphino)methyl)-3,3-bis[1-(2,4,6-trimethylphenyl)methyl]pyrrolidin-2-one

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Technology Process of (S)-5-((diphenylphosphino)methyl)-3,3-bis[1-(2,4,6-trimethylphenyl)methyl]pyrrolidin-2-one

There total 5 articles about (S)-5-((diphenylphosphino)methyl)-3,3-bis[1-(2,4,6-trimethylphenyl)methyl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 627503-55-3
Toluene-4-sulfonic acid (S)-5-oxo-4,4-bis-(2,4,6-trimethyl-benzyl)-pyrrolidin-2-ylmethyl ester

: 627503-60-0
(S)-5-((diphenylphosphino)methyl)-3,3-bis[1-(2,4,6-trimethylphenyl)methyl]pyrrolidin-2-one

Guidance literature:: chloro-diphenylphosphine; With sodium; In 1,4-dioxane; for 15h; Heating;

Toluene-4-sulfonic acid (S)-5-oxo-4,4-bis-(2,4,6-trimethyl-benzyl)-pyrrolidin-2-ylmethyl ester; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/jo035234q

Reference yield:

: 4761-00-6
2,4,6-trimethylbenzylbromide

: 627503-60-0
(S)-5-((diphenylphosphino)methyl)-3,3-bis[1-(2,4,6-trimethylphenyl)methyl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi; HMDS / hexane; tetrahydrofuran / 1 h / 20 °C

1.2: 69 percent / n-BuLi; HMDS; HMPA / hexane; tetrahydrofuran / 3 h / 20 °C

2.1: 79 percent / p-TsOH*H₂O / methanol / 36 h / Heating

3.1: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

4.1: Na / dioxane / 15 h / Heating

4.2: 46 percent / dioxane; tetrahydrofuran / 1 h / 20 °C

With dmap; n-butyllithium; sodium; toluene-4-sulfonic acid; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;
DOI:10.1021/jo035234q

Reference yield:

: 99208-71-6
(5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane

: 627503-60-0
(S)-5-((diphenylphosphino)methyl)-3,3-bis[1-(2,4,6-trimethylphenyl)methyl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi; HMDS / hexane; tetrahydrofuran / 1 h / 20 °C

1.2: 69 percent / n-BuLi; HMDS; HMPA / hexane; tetrahydrofuran / 3 h / 20 °C

2.1: 79 percent / p-TsOH*H₂O / methanol / 36 h / Heating

3.1: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

4.1: Na / dioxane / 15 h / Heating

4.2: 46 percent / dioxane; tetrahydrofuran / 1 h / 20 °C

With dmap; n-butyllithium; sodium; toluene-4-sulfonic acid; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;
DOI:10.1021/jo035234q