Cyclopropyl(4-methoxyphenyl)methanone

Base Information

• Chemical Name: Cyclopropyl(4-methoxyphenyl)methanone
• CAS No.: 7152-03-6
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Hs Code.: 2914509090
• European Community (EC) Number: 230-487-7
• NSC Number: 71980
• UNII: B2980CXL3R
• DSSTox Substance ID: DTXSID7064576
• Nikkaji Number: J227.412D
• Wikidata: Q72460995
• ChEMBL ID: CHEMBL82673
• Mol file: 7152-03-6.mol

Synonyms:Cyclopropyl(4-methoxyphenyl)methanone;Cyclopropyl 4-methoxyphenyl ketone;7152-03-6;Methanone, cyclopropyl(4-methoxyphenyl)-;cyclopropyl-(4-methoxyphenyl)methanone;p-Anisoylcyclopropane;MFCD00001296;CHEMBL82673;MLS002693748;B2980CXL3R;EINECS 230-487-7;NSC 71980;NSC-71980;Cyclopropyl-(4-methoxy-phenyl)-methanone;Maybridge3_006117;p-anisyl cyclopropyl ketone;4-Methoxybenzoylcyclopropane;Cyclopropyl p-anisyl ketone;UNII-B2980CXL3R;SCHEMBL1148371;DTXSID7064576;cyclopropyl-(4-methoxy-phenyl)-;HMS1448G01;HMS3086A11;NSC71980;BBL034623;BDBM50145832;STL415804;AKOS000120594;CYCLOPROPYL4-METHOXYPHENYLKETONE;IDI1_017504;Cyclopropyl 4-methoxyphenyl ketone, 98%;CYCLOPROPYL P-METHOXYPHENYL KETONE;4-METHOXYPHENYL CYCLOPROPYL KETONE;LS-91185;SMR000783534;TS-02440;KETONE, CYCLOPROPYL P-METHOXYPHENYL;CS-0204532;FT-0624295;EN300-21021;F87444

Chemical Property of Cyclopropyl(4-methoxyphenyl)methanone

Chemical Property:

• Appearance/Colour: light yellow to light brown crystalline solid
• Vapor Pressure: 0.000903mmHg at 25°C
• Melting Point: 40-42 °C(lit.)
• Refractive Index: 1.563
• Boiling Point: 303.9 °C at 760 mmHg
• Flash Point: 140 °C
• PSA: 26.30000
• Density: 1.142 g/cm³
• LogP: 2.28790
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 176.083729621
• Heavy Atom Count: 13
• Complexity: 188

Purity/Quality:

99% ^*data from raw suppliers

Cyclopropyl 4-methoxyphenyl ketone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2CC2

Technology Process of Cyclopropyl(4-methoxyphenyl)methanone

There total 34 articles about Cyclopropyl(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chloro-1-(4-methoxyphenyl)butan-1-one (40877-19-8) → p-methoxyphenyl cyclopropyl ketone (7152-03-6)

Guidance literature:

With potassium hydroxide; In methanol; for 12h; Ambient temperature;

DOI:10.1021/jo00073a047

Reference yield: 91.0%

methoxybenzene (100-66-3) + cyclopropanecarboxylic acid (1759-53-1) → p-methoxyphenyl cyclopropyl ketone (7152-03-6)

Guidance literature:

With trifluoroacetic acid; trifluoroacetic anhydride; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.01.026

Reference yield: 83.0%

cyclopropanecarboxylic acid chloride (4023-34-1) + methoxybenzene (100-66-3) → p-methoxyphenyl cyclopropyl ketone (7152-03-6)

Guidance literature:

With copper(II) ferrite; In 1,2-dichloro-ethane; at 35 - 38 ℃; for 18h;

DOI:10.1016/j.tetlet.2013.01.081

upstream raw materials:

cyclopropanecarboxylic acid chloride

methoxybenzene

4-Chlorobutanoyl chloride

2,2,2-trifluoroethanol

Downstream raw materials:

ancymidole

α,α-dicyclopropyl(4-methoxyphenyl)methanol

α-(4-methoxyphenyl)-α-(4-trifluoromethylphenyl)cyclopropylmethanol

1-cyclopropyl-1-(4-methoxyphenyl)-3-(pyridin-2-yl)prop-2-yn-1-ol

Refernces

• 1、 -. "Aryl or heteroaryl methoxylation reaction method". Paragraph 0106-0112. . Retrieved 2021/11/21.
• 2、 Ma, Yueyue,Lv, Jufeng,Liu, Chengyu,Yao, Xiantong,Yan, Guoming,Yu, Wei,Ye, Jinxing. "Electrochemical [4+2] Annulation-Rearrangement-Aromatization of Styrenes: Synthesis of Naphthalene Derivatives". supporting information. p. 6756 - 6760. Retrieved 2019/04/17.