{2-[(4-Chlorophenyl)dimethylsilyl]phenyl}methanol

Base Information

• Chemical Name: {2-[(4-Chlorophenyl)dimethylsilyl]phenyl}methanol
• CAS No.: 1217863-25-6
• Molecular Formula: C₁₅H₁₇ClOSi
• Molecular Weight: 276.838
• Hs Code.: 2905190098
• Mol file: 1217863-25-6.mol

Synonyms:[2-(hydroxymethyl)phenyl]dimethyl(4-chlorophenyl)silane

Chemical Property of {2-[(4-Chlorophenyl)dimethylsilyl]phenyl}methanol

Chemical Property:

• Boiling Point: 365.8±42.0 °C(Predicted)
• PKA: 14.44±0.10(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

{2-[(4-Chloro-phenyl)-dimethyl-silanyl]-phenyl}-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[(4-Chlorophenyl)dimethylsilyl]phenyl}methanol

There total 4 articles about {2-[(4-Chlorophenyl)dimethylsilyl]phenyl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

bromochlorobenzene (106-39-8) + 1,1-dimethyl-1,3-dihydrobenzo[c][1,2]oxasilole (321903-29-1) → [2-(hydroxymethyl)phenyl]dimethyl(4-chlorophenyl)silane (1217863-25-6)

Guidance literature:

In tetrahydrofuran;

DOI:10.1016/j.tetlet.2011.10.126

Reference yield:

o-bromobenzyl alcohol (18982-54-2) → [2-(hydroxymethyl)phenyl]dimethyl(4-chlorophenyl)silane (1217863-25-6)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / water / 20 °C

2: n-butyllithium

3: methanol / Acidic conditions

4: tetrahydrofuran

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.tetlet.2011.10.126

Reference yield:

2-(tetrahydropyranyloxy)methylbromobenzene (17100-66-2) → [2-(hydroxymethyl)phenyl]dimethyl(4-chlorophenyl)silane (1217863-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: n-butyllithium

2: methanol / Acidic conditions

3: tetrahydrofuran

With n-butyllithium; In tetrahydrofuran; methanol;

DOI:10.1016/j.tetlet.2011.10.126

upstream raw materials:

dimethyl(2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)silane

bromochlorobenzene

1,1-dimethyl-1,3-dihydrobenzo[c][1,2]oxasilole

2-(tetrahydropyranyloxy)methylbromobenzene

Downstream raw materials:

1-chloro-4-(2-methylprop-2-en-1-yl)benzene

para-chlorobenzoic acid

N,N-dibenzyl-(4-chlorophenyl)amine

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