1-Bromo-2-(2-tetrahydropyranyloxymethyl)benzene

Base Information

• Chemical Name: 1-Bromo-2-(2-tetrahydropyranyloxymethyl)benzene
• CAS No.: 17100-66-2
• Molecular Formula: C12H15BrO2
• Molecular Weight: 271.154
• DSSTox Substance ID: DTXSID60415676
• Nikkaji Number: J1.785.159D
• Mol file: 17100-66-2.mol

Synonyms:1-bromo-2-(2-tetrahydropyranyloxymethyl)benzene;ghl.PD_Mitscher_leg0.1244;17100-66-2;SCHEMBL2006340;DTXSID60415676;RTKKOPXYLQWHBJ-UHFFFAOYSA-N;2-(2-tetrahydro-2H-pyranoxymethyl)bromobenzene;1-bromo-2-(2-tetrahydro-pyranyloxymethyl)benzene;1-bromo-2-(2-tetrahydropyranyloxymethyl)-benzene;1-bromo-2-(tetrahydropyran-2-yloxy-methyl)benzene;1-bromo-2-(tetrahydropyran-2-yloxymethyl)benzene;1-(Tetrahydro-2H-pyran-2-yloxymethyl)-2-bromobenzene

Chemical Property of 1-Bromo-2-(2-tetrahydropyranyloxymethyl)benzene

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 270.02554
• Heavy Atom Count: 15
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCOC(C1)OCC2=CC=CC=C2Br

Technology Process of 1-Bromo-2-(2-tetrahydropyranyloxymethyl)benzene

There total 4 articles about 1-Bromo-2-(2-tetrahydropyranyloxymethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + o-bromobenzyl alcohol (18982-54-2) → 2-(tetrahydropyranyloxy)methylbromobenzene (17100-66-2)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 0 - 20 ℃; for 2.5h;

DOI:10.1007/s11164-011-0422-8

Reference yield: 94.0%

3,4-dihydro-2H-pyran (110-87-2) + (3-Bromophenyl)methanol (15852-73-0) → 2-(tetrahydropyranyloxy)methylbromobenzene (17100-66-2)

Guidance literature:

With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide; at 20 ℃; for 0.1h; Neat (no solvent);

DOI:10.1007/BF03246014

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + o-bromobenzyl alcohol (18982-54-2) + sodium hydrogencarbonate (144-55-8) → 2-(tetrahydropyranyloxy)methylbromobenzene (17100-66-2)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane;

upstream raw materials:

3,4-dihydro-2H-pyran

o-bromobenzyl alcohol

sodium hydrogencarbonate

(3-Bromophenyl)methanol

Downstream raw materials:

2-[2-(2-Biphenyl-4-yl-oxiranyl)-benzyloxy]-tetrahydro-pyran

2-(1-methyl-2-propenyl)benzenemethanol

2-((Z)-but-2-en-1-yl)benzyl alcohol

2-((E)-but-2-en-1-yl)benzyl alcohol