4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

Base Information

Chemical Name:4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester
CAS No.:1232234-95-5
Molecular Formula:C₂₇H₂₉ClN₄O₃S
Molecular Weight:525.071
Hs Code.:

Synonyms:4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

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Chemical Property of 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

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Technology Process of 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

There total 12 articles about 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1232234-94-4
4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

: 1232234-95-5
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; for 6h; Reflux;

Reference yield:

: 1232234-37-5
4-dimethoxymethyl-2-fluoro-1-nitro-benzene

: 1232234-95-5
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: hydrogenchloride; water / acetonitrile / 0.5 h / 60 °C

3.1: ammonium chloride; zinc / tetrahydrofuran / 1 h

4.1: acetic acid / 1 h

4.2: pH 9

5.1: phenyllithium / tetrahydrofuran / -78 °C

5.2: 20 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2585.81 Torr

7.1: boron dimethyl-trifluoro sulphide / acetonitrile / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

9.1: potassium carbonate / acetonitrile / 6 h / Reflux

With hydrogenchloride; boron dimethyl-trifluoro sulphide; water; hydrogen; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; phenyllithium; N-ethyl-N,N-diisopropylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1H-1,3-benzodiazole-6-carbaldehyde

: 1232234-95-5
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

1.2: 1 h / 20 °C

2.1: phenyllithium / tetrahydrofuran / -78 °C

2.2: 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2585.81 Torr

4.1: boron dimethyl-trifluoro sulphide / acetonitrile / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: potassium carbonate / acetonitrile / 6 h / Reflux

With boron dimethyl-trifluoro sulphide; hydrogen; sodium hydride; potassium carbonate; phenyllithium; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;