8-(1-((3,5-difluorophenyl)(methyl) amino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Base Information

Chemical Name:8-(1-((3,5-difluorophenyl)(methyl) amino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide
CAS No.:1296271-29-8
Molecular Formula:C₂₆H₂₉F₂N₃O₄
Molecular Weight:485.531
Hs Code.:

Synonyms:8-(1-((3,5-difluorophenyl)(methyl) amino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

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Chemical Property of 8-(1-((3,5-difluorophenyl)(methyl) amino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

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Technology Process of 8-(1-((3,5-difluorophenyl)(methyl) amino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

There total 13 articles about 8-(1-((3,5-difluorophenyl)(methyl) amino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1296271-51-6
8-(1-((3,5-difluorophenyl)(methyl)amino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid

: 124-40-3
dimethyl amine

: 1296271-29-8
8-(1-((3,5-difluorophenyl)(methyl) amino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 63.0%

: 1296271-87-8
8-(1-((3,5-difluorophenyl)(methyl)amino)ethyl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylic acid

: 124-40-3
dimethyl amine

: 1296271-29-8
8-(1-((3,5-difluorophenyl)(methyl) amino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 29415-97-2
methyl 3-bromo-4-hydroxybenzoate

: 1296271-29-8
8-(1-((3,5-difluorophenyl)(methyl) amino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / palladium diacetate; (diphenylphosphin)ferrocene / diethyl ether; ethanol / 70 °C / Inert atmosphere

1.2: 2 h

2.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C

2.2: 5 °C

3.1: boron trifluoride diethyl etherate / toluene; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol / 20 °C / Inert atmosphere

3.2: 12 h / 90 °C

4.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 90 °C / Inert atmosphere

4.2: 0.5 h / 45 °C

5.1: sodium tetrahydroborate / dichloromethane; methanol / 0.25 h / -10 °C

6.1: phosphorus tribromide / dichloromethane / 36 h / 20 °C / Inert atmosphere; Cooling with ice

6.2: pH 6 / Cooling with ice

7.1: chloroform; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol / 20 °C

7.2: pH 6 - 7

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

8.2: pH 3

9.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; pyridine; sodium tetrahydroborate; boron trifluoride diethyl etherate; water; bromine; phosphorus tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; (diphenylphosphin)ferrocene; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; chloroform; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide; toluene;