1-(2,4-dinitrophenyl)-imidazole 4-acetic acid N-hydroxysuccinimide ester

Base Information

• Chemical Name: 1-(2,4-dinitrophenyl)-imidazole 4-acetic acid N-hydroxysuccinimide ester
• CAS No.: 153527-32-3
• Molecular Formula: C₁₅H₁₁N₅O₈
• Molecular Weight: 389.281
• Mol file: 153527-32-3.mol

Synonyms:1-(2,4-dinitrophenyl)-imidazole 4-acetic acid N-hydroxysuccinimide ester

Chemical Property of 1-(2,4-dinitrophenyl)-imidazole 4-acetic acid N-hydroxysuccinimide ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,4-dinitrophenyl)-imidazole 4-acetic acid N-hydroxysuccinimide ester

There total 5 articles about 1-(2,4-dinitrophenyl)-imidazole 4-acetic acid N-hydroxysuccinimide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + [1-(2,4-dinitrophenyl)-1H-imidazol-4-yl]acetic acid (153527-31-2) → 1-(2,4-dinitrophenyl)-imidazole 4-acetic acid N-hydroxysuccinimide ester (153527-32-3)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1016/S0040-4039(00)61685-4

Reference yield:

2,4-Dinitrofluorobenzene (70-34-8,65727-75-5) → 1-(2,4-dinitrophenyl)-imidazole 4-acetic acid N-hydroxysuccinimide ester (153527-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / tetrahydrofuran / 20 °C

2: 70 mg / DCC / dimethylformamide / 0 - 20 °C

With dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/b504330a

Reference yield:

imidazole-4-acetic acid sodium salt → 1-(2,4-dinitrophenyl)-imidazole 4-acetic acid N-hydroxysuccinimide ester (153527-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / tetrahydrofuran / 20 °C

2: 70 mg / DCC / dimethylformamide / 0 - 20 °C

With dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/b504330a

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

[1-(2,4-dinitrophenyl)-1H-imidazol-4-yl]acetic acid

2,4-Dinitrofluorobenzene

2-(1H-imidazol-4-yl)acetic acid

Downstream raw materials:

N-[2-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-ylamino)-ethyl]-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-acetamide

N-(2-{9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-ethyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-acetamide