1-(N,N-dimethylcarbamoylmethyl)-4,7,10-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: 1-(N,N-dimethylcarbamoylmethyl)-4,7,10-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane
• CAS No.: 132930-12-2
• Molecular Formula: C₃₃H₄₅N₅O₇S₃
• Molecular Weight: 719.948
• Mol file: 132930-12-2.mol

Synonyms:1-(N,N-dimethylcarbamoylmethyl)-4,7,10-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane

Chemical Property of 1-(N,N-dimethylcarbamoylmethyl)-4,7,10-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(N,N-dimethylcarbamoylmethyl)-4,7,10-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane

There total 2 articles about 1-(N,N-dimethylcarbamoylmethyl)-4,7,10-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromo-N,N-dimethylethanamide (5468-77-9) + 1,4,7-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane (94530-07-1) → 1-(N,N-dimethylcarbamoylmethyl)-4,7,10-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane (132930-12-2)

Guidance literature:

With potassium carbonate; In acetonitrile; for 20h; Heating;

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 1-(N,N-dimethylcarbamoylmethyl)-4,7,10-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane (132930-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 11 percent / triethylamine / CH₂Cl₂ / 2 h / 0 °C

2: 90 percent / potassium carbonate / acetonitrile / 20 h / Heating

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

Reference yield: 48.0%

1-(N,N-dimethylcarbamoylmethyl)-4,7,10-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane (132930-12-2) → (N,N-dimethylcarbamoylmethyl)-4-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane trihydrobromide

Guidance literature:

With hydrogen bromide; acetic acid; phenol; at 80 ℃; for 336h;

upstream raw materials:

2-bromo-N,N-dimethylethanamide

1,4,7-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane

p-toluenesulfonyl chloride