N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(tert-butoxycarbonylamino)acetamide

Base Information

• Chemical Name: N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(tert-butoxycarbonylamino)acetamide
• CAS No.: 880545-43-7
• Molecular Formula: C₁₉H₂₉BN₂O₅
• Molecular Weight: 376.261

Synonyms:N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(tert-butoxycarbonylamino)acetamide

Chemical Property of N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(tert-butoxycarbonylamino)acetamide

Chemical Property:

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SDS file from LookChem

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Technology Process of N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(tert-butoxycarbonylamino)acetamide

There total 2 articles about N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(tert-butoxycarbonylamino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

BOC-glycine (4530-20-5) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) → N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(tert-butoxycarbonylamino)acetamide (880545-43-7)

Guidance literature:

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 40 ℃; for 3h;

DOI:10.1039/c3cc45275a

Reference yield:

BOC-glycine (4530-20-5) + HATU (200731-31-3,148893-10-1) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) → 1-hydroxy-7-aza-benzotriazole (39968-33-7) + N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(tert-butoxycarbonylamino)acetamide (880545-43-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 20 ℃; for 2h;

Reference yield: 100.0%

N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(tert-butoxycarbonylamino)acetamide (880545-43-7) → C14H21BN2O3 (880545-42-6)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2005.11.065

upstream raw materials:

BOC-glycine

HATU

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

Downstream raw materials:

C₁₄H₂₁BN₂O₃

4-(4-glycylaminophenyl)-6-morpholino-2-(2-trifluoromethylbenzimidazol-1-yl)pyrimidine

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