(S)-1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylthio)phenyl)-3-(tetrahydrofuran-3-yl)urea

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Chemical Name:(S)-1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylthio)phenyl)-3-(tetrahydrofuran-3-yl)urea
CAS No.:1299488-35-9
Molecular Formula:C₂₆H₂₉F₆N₃O₃S
Molecular Weight:577.591
Hs Code.:

Synonyms:(S)-1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylthio)phenyl)-3-(tetrahydrofuran-3-yl)urea

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Chemical Property of (S)-1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylthio)phenyl)-3-(tetrahydrofuran-3-yl)urea

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Technology Process of (S)-1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylthio)phenyl)-3-(tetrahydrofuran-3-yl)urea

There total 6 articles about (S)-1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylthio)phenyl)-3-(tetrahydrofuran-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185756-83-5,204512-94-7
(S)-tetrahydrofuran-3-amine hydrochloride salt

: 1299488-38-2
2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

: 7693-46-1
4-Nitrophenyl chloroformate

: 1299488-35-9
(S)-1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylthio)phenyl)-3-(tetrahydrofuran-3-yl)urea

Guidance literature:: 2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol; 4-Nitrophenyl chloroformate; In dichloromethane; at 20 ℃; for 1h;

(S)-tetrahydrofuran-3-amine hydrochloride salt; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h;

Reference yield:

: 1849-36-1
para-nitrobenzenethiol

: 1299488-35-9
(S)-1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylthio)phenyl)-3-(tetrahydrofuran-3-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 60 °C

2.1: hydrogen / palladium / ethanol / 3750.38 Torr

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.1: potassium carbonate / acetonitrile / 1 h / 20 °C

5.1: dichloromethane / 1 h / 20 °C

5.2: 0.5 h

With hydrogen; sodium hydride; potassium carbonate; trifluoroacetic acid; palladium; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 333986-94-0
4-(4-nitrophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester

: 1299488-35-9
(S)-1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-ylthio)phenyl)-3-(tetrahydrofuran-3-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium / ethanol / 3750.38 Torr

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3.1: potassium carbonate / acetonitrile / 1 h / 20 °C

4.1: dichloromethane / 1 h / 20 °C

4.2: 0.5 h

With hydrogen; potassium carbonate; trifluoroacetic acid; palladium; In ethanol; dichloromethane; acetonitrile;