2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Base Information

Chemical Name:2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
CAS No.:1299488-38-2
Molecular Formula:C₂₁H₂₂F₆N₂OS
Molecular Weight:464.475
Hs Code.:

Synonyms:2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

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Chemical Property of 2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

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Technology Process of 2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

There total 5 articles about 2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 202134-57-4
2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

: 1250505-22-6
4-(piperidin-4-ylthio)aniline

: 1299488-38-2
2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 333986-94-0
4-(4-nitrophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester

: 1299488-38-2
2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium / ethanol / 3750.38 Torr

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: potassium carbonate / acetonitrile / 1 h / 20 °C

With hydrogen; potassium carbonate; trifluoroacetic acid; palladium; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1849-36-1
para-nitrobenzenethiol

: 1299488-38-2
2-(4-((4-(4-aminophenylthio)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 60 °C

2.1: hydrogen / palladium / ethanol / 3750.38 Torr

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.1: potassium carbonate / acetonitrile / 1 h / 20 °C

With hydrogen; sodium hydride; potassium carbonate; trifluoroacetic acid; palladium; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;