1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N⁴-phenylpiperazinyl)>propane

Base Information

• Chemical Name: 1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N⁴-phenylpiperazinyl)>propane
• CAS No.: 119321-61-8
• Molecular Formula: C₂₆H₃₀N₄O₄S
• Molecular Weight: 494.615

Synonyms:1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N⁴-phenylpiperazinyl)>propane

Chemical Property of 1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N⁴-phenylpiperazinyl)>propane

Chemical Property:

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Technology Process of 1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N⁴-phenylpiperazinyl)>propane

There total 5 articles about 1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N⁴-phenylpiperazinyl)>propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-(3-chloropropyl)-4-phenylpiperazine (10599-17-4) + Methyl 1-<4-Hydroxyphenyl>-2-methylmercapto-6-oxopyrimidine-4-carboxylate (119321-59-4) → 1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N4-phenylpiperazinyl)>propane (119321-61-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

1-(4-hydroxyphenyl)thiourea (1520-27-0) → 1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N4-phenylpiperazinyl)>propane (119321-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / methanol / 4 h / Heating

2: 66 percent / ethanol

3: 64 percent / K₂CO₃ / dimethylformamide / 70 °C

With potassium carbonate; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

N1-Benzoyl-N2-<4-hydroxyphenyl>thiourea (5461-34-7) → 1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N4-phenylpiperazinyl)>propane (119321-61-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / 10 percent NaOH / 2 h / 90 °C

2: 91 percent / methanol / 4 h / Heating

3: 66 percent / ethanol

4: 64 percent / K₂CO₃ / dimethylformamide / 70 °C

With sodium hydroxide; potassium carbonate; In methanol; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

1-(3-chloropropyl)-4-phenylpiperazine

Methyl 1-<4-Hydroxyphenyl>-2-methylmercapto-6-oxopyrimidine-4-carboxylate

1-(4-hydroxyphenyl)thiourea

N¹-Benzoyl-N²-<4-hydroxyphenyl>thiourea

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