2-(4-{6-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-hexyl}-piperazin-1-yl)-ethanol; hydrochloride

Base Information

Chemical Name:2-(4-{6-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-hexyl}-piperazin-1-yl)-ethanol; hydrochloride
CAS No.:83547-21-1
Molecular Formula:10C₃₀H₃₉F₃N₄O₃*29ClH
Molecular Weight:6663.97
Hs Code.:

Synonyms:2-(4-{6-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-hexyl}-piperazin-1-yl)-ethanol; hydrochloride

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Chemical Property of 2-(4-{6-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-hexyl}-piperazin-1-yl)-ethanol; hydrochloride

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Technology Process of 2-(4-{6-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-hexyl}-piperazin-1-yl)-ethanol; hydrochloride

There total 5 articles about 2-(4-{6-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-hexyl}-piperazin-1-yl)-ethanol; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 6-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-hexanoic acid [6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-amide

: 83547-21-1
2-(4-{6-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-hexyl}-piperazin-1-yl)-ethanol; hydrochloride

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at -20 - 0 ℃;
DOI:10.1021/jm00356a013

Reference yield:

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 83547-21-1
2-(4-{6-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-hexyl}-piperazin-1-yl)-ethanol; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / Heating

2: 53 percent / AlCl₃, LiAlH₄ / tetrahydrofuran / -20 - 0 °C

With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; benzene;
DOI:10.1021/jm00356a013

Reference yield:

: 22809-37-6
6-bromohexanoyl chloride

: 83547-21-1
2-(4-{6-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-hexyl}-piperazin-1-yl)-ethanol; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / Na₂CO₃ / acetone / 3 h / Heating

2: benzene / Heating

3: 53 percent / AlCl₃, LiAlH₄ / tetrahydrofuran / -20 - 0 °C

With lithium aluminium tetrahydride; aluminium trichloride; sodium carbonate; In tetrahydrofuran; acetone; benzene;
DOI:10.1021/jm00356a013