(R)-2-Benzyl-3-(4-propoxy-3-((4-(pyrimidin-2-yl)benzamido)methyl)phenyl)propanoic acid

Base Information

• Chemical Name: (R)-2-Benzyl-3-(4-propoxy-3-((4-(pyrimidin-2-yl)benzamido)methyl)phenyl)propanoic acid
• CAS No.: 1361404-15-0
• Molecular Formula: C₃₁H₃₁N₃O₄
• Molecular Weight: 509.605
• Mol file: 1361404-15-0.mol

Synonyms:(R)-2-Benzyl-3-(4-propoxy-3-((4-(pyrimidin-2-yl)benzamido)methyl)phenyl)propanoic acid

Chemical Property of (R)-2-Benzyl-3-(4-propoxy-3-((4-(pyrimidin-2-yl)benzamido)methyl)phenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Benzyl-3-(4-propoxy-3-((4-(pyrimidin-2-yl)benzamido)methyl)phenyl)propanoic acid

There total 12 articles about (R)-2-Benzyl-3-(4-propoxy-3-((4-(pyrimidin-2-yl)benzamido)methyl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C41H40N4O5 (1441810-31-6) → (R)-2-Benzyl-3-(4-propoxy-3-((4-(pyrimidin-2-yl)benzamido)methyl)phenyl)propanoic acid (1361404-15-0)

Guidance literature:

With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 3.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.02.003

Reference yield:

2-hydroxy-5-formylbenzoic acid (616-76-2) → (R)-2-Benzyl-3-(4-propoxy-3-((4-(pyrimidin-2-yl)benzamido)methyl)phenyl)propanoic acid (1361404-15-0)

Guidance literature:

Multi-step reaction with 12 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 60 °C

3: sodium tetrahydroborate / ethanol / 2 h / 20 °C

4: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C

5: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -50 - 0 °C

6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C

7: borane-THF / tetrahydrofuran / 0 °C

8: manganese(IV) oxide / dichloromethane / 20 °C

9: hydroxylamine hydrochloride; pyridine / ethanol / 20 °C

10: palladium 10% on activated carbon; hydrogenchloride; hydrogen / water; ethanol / 3 h / 20 °C / 3000.3 - 3750.38 Torr

11: diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

12: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 3.5 h / 0 °C / Inert atmosphere

With pyridine; hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; borane-THF; lithium hydroxide monohydrate; diethyl cyanophosphonate; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; dihydrogen peroxide; phosphorus tribromide; potassium carbonate; potassium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.02.003

Reference yield:

benzyl 2-propoxy-5-formylsalicylate (1259391-04-2) → (R)-2-Benzyl-3-(4-propoxy-3-((4-(pyrimidin-2-yl)benzamido)methyl)phenyl)propanoic acid (1361404-15-0)

Guidance literature:

Multi-step reaction with 10 steps

1: sodium tetrahydroborate / ethanol / 2 h / 20 °C

2: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -50 - 0 °C

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C

5: borane-THF / tetrahydrofuran / 0 °C

6: manganese(IV) oxide / dichloromethane / 20 °C

7: hydroxylamine hydrochloride; pyridine / ethanol / 20 °C

8: palladium 10% on activated carbon; hydrogenchloride; hydrogen / water; ethanol / 3 h / 20 °C / 3000.3 - 3750.38 Torr

9: diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

10: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 3.5 h / 0 °C / Inert atmosphere

With pyridine; hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; borane-THF; lithium hydroxide monohydrate; diethyl cyanophosphonate; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; dihydrogen peroxide; phosphorus tribromide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.02.003

upstream raw materials:

2-hydroxy-5-formylbenzoic acid

benzyl 2-hydroxy-5-formylbenzoate

benzyl 2-propoxy-5-formylsalicylate

benzyl 5-hydroxymethyl-2-propoxybenzoate