methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-{[(3-cyanophenyl)(methyl)carbamoyl]methyl}anthranilate

Base Information

Chemical Name:methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-{[(3-cyanophenyl)(methyl)carbamoyl]methyl}anthranilate
CAS No.:540765-42-2
Molecular Formula:C₂₈H₃₄N₄O₆
Molecular Weight:522.601
Hs Code.:

Synonyms:methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-{[(3-cyanophenyl)(methyl)carbamoyl]methyl}anthranilate

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Chemical Property of methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-{[(3-cyanophenyl)(methyl)carbamoyl]methyl}anthranilate

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Technology Process of methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-{[(3-cyanophenyl)(methyl)carbamoyl]methyl}anthranilate

There total 4 articles about methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-{[(3-cyanophenyl)(methyl)carbamoyl]methyl}anthranilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 540765-41-1
2-bromo-N-(3-cyanophenyl)-N-methylacetamide

: 179756-40-2
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anthranilate

: 540765-42-2
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-{[(3-cyanophenyl)(methyl)carbamoyl]methyl}anthranilate

Guidance literature:: With potassium carbonate; In acetonitrile; for 12h; Heating;
DOI:10.1016/S0968-0896(02)00462-5

Reference yield:

: 64910-52-7
3-(methylamino)benzonitrile

: 540765-42-2
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-{[(3-cyanophenyl)(methyl)carbamoyl]methyl}anthranilate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaHCO₃ / ethyl acetate; H₂O / 0.25 h / 20 °C

2: 35 percent / K₂CO₃ / acetonitrile / 12 h / Heating

With sodium hydrogencarbonate; potassium carbonate; In water; ethyl acetate; acetonitrile;
DOI:10.1016/S0968-0896(02)00462-5

Reference yield:

: 1882-72-0
methyl 2-amino-5-hydroxybenzoate

: 540765-42-2
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-{[(3-cyanophenyl)(methyl)carbamoyl]methyl}anthranilate

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / PPh₃; DEAD / tetrahydrofuran / 96 h / 20 °C

2: 35 percent / K₂CO₃ / acetonitrile / 12 h / Heating

With potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; acetonitrile; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(02)00462-5