Methyl 2-amino-5-hydroxybenzoate

Base Information

• Chemical Name: Methyl 2-amino-5-hydroxybenzoate
• CAS No.: 1882-72-0
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Hs Code.: 2922509090
• European Community (EC) Number: 811-120-5
• DSSTox Substance ID: DTXSID80356138
• Nikkaji Number: J741.027A
• Wikidata: Q82135334
• Mol file: 1882-72-0.mol

Synonyms:methyl 2-amino-5-hydroxybenzoate;1882-72-0;Benzoic acid, 2-amino-5-hydroxy-, methyl ester;2-amino-5-hydroxybenzoic acid methyl ester;MFCD05863263;BENZOICACID, 2-AMINO-5-HYDROXY-, METHYL ESTER;Methyl 5-Hydroxyanthranilate;SCHEMBL268601;DTXSID80356138;methyl 3-hydroxy- 6-aminobenzoate;AMY14564;AKOS010561225;5-Hydroxyanthranilic Acid Methyl Ester;CS-W006604;GS-4235;PB41526;4-hydroxy-2-(methoxycarbonyl)benzenamine;SY043028;2-Methyl-2-(1H-pyrrol-1-yl)propanoicacid;2-amino-5-hydroxy-benzoic acid methyl ester;FT-0645961;M2796;EN300-122248;A880525;AN-584/43164258;J-521934;Z802838778

Chemical Property of Methyl 2-amino-5-hydroxybenzoate

Chemical Property:

• Vapor Pressure: 1.33E-05mmHg at 25°C
• Melting Point: 158.0 to 162.0 °C
• Refractive Index: 1.605
• Boiling Point: 357.4 °C at 760 mmHg
• PKA: 9.41±0.18(Predicted)
• Flash Point: 170 °C
• PSA: 72.55000
• Density: 1.305 g/cm³
• LogP: 1.34220
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: slightly sol. in Methanol
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 167.058243149
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Amino-5-hydroxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=C(C=CC(=C1)O)N

Technology Process of Methyl 2-amino-5-hydroxybenzoate

There total 12 articles about Methyl 2-amino-5-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 2-amino-5-hydroxybenzoic acid (394-31-0) → methyl 2-amino-5-hydroxybenzoate (1882-72-0)

Guidance literature:

With sulfuric acid; for 48h; Reflux;

DOI:10.1002/anie.201602797

Reference yield: 95.0%

→ methyl 2-amino-5-hydroxybenzoate (1882-72-0)

Guidance literature:

resin-bound 4-azido-3-methoxycarbonylphenol; With aluminium; nickel dichloride; at 20 ℃; for 25h;

With trifluoroacetic acid;

DOI:10.1016/S0040-4039(03)01049-9

Reference yield: 86.0%

2-azido-5-hydroxy-benzoic acid methyl ester → methyl 2-amino-5-hydroxybenzoate (1882-72-0)

Guidance literature:

2-azido-5-hydroxy-benzoic acid methyl ester; With trichloromethane sulfonic Acid; Wang resin trichloroacetimidate; In dichloromethane; for 0.166667h;

With indium; ammonium chloride; for 4h; Heating;

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(01)01435-6

upstream raw materials:

methanol

2-amino-5-hydroxybenzoic acid

methyl 2-nitrobenzoate

Avenalumin 1

Downstream raw materials:

2-(2-chloro-acetylamino)-5-hydroxy-benzoic acid methyl ester

methyl 2-amino-5-methoxybenzoate

methyl 2-phthalimido-5-hydroxybenzoate

2-acetylamino-5-hydroxybenzoic acid methyl ester